Why does it make good metabolic sense for phosphoenolpyruvate carboxykinase, rather than pyruvate carboxylase, to be the primary target for the regulation of gluconeogenesis at the level of control of enzymesynthesis?Match the words in the left column to the appropriate blanks in the sentences on the right.fructose-1,6-bisphosphatepyruvate3-phosphoglycerateincreasingreducingglycolytic pathwayforwardacetaldehydelactatephosphoenolpyruvateoxaloacetatecitric acid cyclebackglyceraldehyde-3-phosphateFirstly, pyruvate carboxylase convertswhich can participate in thegluconeogenesis pathway, and also plays an additional metabolic role in aiding the entry ofintermediates into theHence, it makes sense for phosphoenolpyruvatecarboxykinase (PEPCK) to catalyze the conversion ofgluconeogenesis pathway, therebypyruvate carboxylase.totoThirdly, PEPCK action results in the formation ofamino acids and their subsequent entry into the citric acid cycle.Reset Helpto push thethe metabolic regulatory load onSecondly, PEPCK aids the formation of dihydroxyacetone phosphate andcan then participate in the synthesis of fatty acids/steroids.which, which aids in the synthesis of

Gluconeogenesis is the metabolic pathway that produces glucose or glucose 6-phosphate from non…

Answered: Why does it make good metabolic sense…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Trace the pathway of [1-14C]pyruvate through gluconeogenesis. Use an asterisk to indicate the location of 14C in all intermediates and in the final gluconeogenesis product, glucose. CH₂ -C=0 Coo [1-1C]Pyruvate CH,OPO H-C-OH C-OPO || 1,3-Bisphospho- glycerate ↑ -coo -CH₂ KC=0 -Coo Oxaloacetate CH,OPO H-C-OH COO 3-Phosphoglycerate CH₂ -OPO OP COO Phosphoenolpyruvate CH,OH H-C-OPO COO 2-Phosphoglycerate
Why does it make good metabolic sense for phosphoenolpyruvate carboxykinase, rather than pyruvate carboxylase, to be the primary target for regulating gluconeogenesis at the level of control of enzyme synthesis?
Why does it make good metabolic sense for phosphoenolpyruvate carboxykinase, rather than pyruvate carboxylase, to be the primary target for regulation of gluconeogenesis at the level of control of enzyme synthesis?
phosphofructokinase reaction of Fructose-2,6-bisphosphate is a regulator of both glycolysis and gluconeogenesis for the glycolysis and the fructose-1,6-bisphosphatase reaction of gluconeogenesis. In turn, the concentration of fructose-2,6-bisphosphate is regulated by many hormones, second messengers, and enzymes. Classify each condition according to its effect on glycolysis and gluconeogenesis Activates glycolysis and inhibits gluconeogenesis activation of PFK-2 increased levels of cAMP Activates gluconeogenesis and inhibits glycolysis increased levels of fructose-2,6-bisphosphate activation of fructose-2,6-bisphosphatase (FBPase-2) increased glucagon levels
Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose‑6‑phosphate. Give two reasons why a Mg2+ cation is required to facilitate this reaction.
phosphofructokinase reaction of Fructose-2,6-bisphosphate is a regulator of both glycolysis and gluconeogenesis for the glycolysis and the fructose-1,6-bisphosphatase reaction of gluconeogenesis. In turn, the concentration of fructose-2,6-bisphosphate is regulated by many hormones, second messengers, and enzymes. Classify each condition according to its effect on glycolysis and gluconeogenesis Activates glycolysis and inhibits gluconeogenesis Activates gluconeogenesis and inhibits glycolysis Answer Bank activation of PFK-2 increased glucagon levels increased levels of cAMP increased levels of fructose-2,6-bisphosphate activation of fructose-2,6-bisphosphatase (FBPase-2)
What is(are) the only active site(s) not used in the second round of fatty acid synthase? Select all that apply. Group of answer choices Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductase
[1,6-(C-14)-2,5-(C-13)]glucose Trace the course of through glycolysis and the TCA cycle. You need only to illustrate the structures of D-glucose, labeling the atoms, and of pyruvate, labeling the origin of the atoms in glucose and the distribution of the carbon isotopes in pyruvate. After one round of the TCA cycle where will the labeled carbons be found?
There are eighteen (18) rows of boxes, for around 36-38 boxes total. Please see images attached. This is a pathway trace, with the final box showing "ribose 5 phosphate" as the end product. Any help is appreciated-thank you! glutamate to ribose 5 phosphate No a ketoglutarate dehydrogenase No pyruvate carboxylase No transketolase No transaminase You do get to have if needed: erythrose 4 phosphate asparate dihydroxyacetone phosphate bicarbonate ATP ornithine CO2
The coenzyme NAD+ is required for which glycolytic reaction shown below? Oglyceraldehyde-3-P→ 1,3-bisphosphoglycerate glucose glucose-6-P fructose-6-P→ fructose-1,6-BP 2-phosphoglycerate → phosphoenolpyruvate
In different organisms sucrose can be cleaved either by hydrolysis or by phosphorolysis. Calculate the ATP yield per mole of sucrose metabolized by anaerobic glycolysis starting with (a) hydrolytic cleavage and (b) phosphorolytic cleavage.
In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number ofATPs you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P АТР ADP Aldolase B Dihydroxy- acetone phosphate Glyceraldehyde АТР Triose kinase Triose phosphate isomerase ADP 4 - Glyceraldehyde-3-P Glycolysis Руruvate Acetyl-CoA Fatty acids and triglycerides

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