Concepts of Genetics (11th Edition)
Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 9, Problem 1PDQ

HOW DO WE KNOW? In this chapter, we focused on extranuclear inheritance and how traits can be determined by genetic information contained in mitochondria and chloroplasts, and we discussed how expression of maternal genotypes can affect the phenotype of an organism. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions?

  1. (a) How was it established that particular phenotypes are inherited as a result of genetic information present in the chloroplast rather than in the nucleus?
  2. (b) How did the discovery of three categories of petite mutations in yeast lead researchers to postulate extranuclear inheritance of colony size?
  3. (c) What observations support the endosymbiotic theory?
  4. (d) What key observations in crosses between dextrally and sinistrally coiled snails support the explanation that this phenotype is the result of maternal-effect inheritance?
  5. (e) What findings demonstrate a maternal effect as the basis of a mode of inheritance?
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Our understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?
In a woman who is a carrier of a mutant OTC deficiency allele, her sons who receive the mutant allele will be affected and her daughters will be carriers who may or may not be symptomatic, depending on random X inactivation in the liver. 1) Is this a single gene inheritance or multifactorial disease? 2) Is there a strong genetic or environmental cause to the development of this disease? If both genetic and environmental causes are implicated, you have to indicate each of them separately.
In most animals, a larger amount of cytoplasm is carried by the egg then by sperm. Similarly, the egg in plants carries more cytoplasm than the pollen. How could this difference affect the expression of inherited traits (a) dependent on nuclear chromosomal genes and (b) dependent on extranuclear genes.

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Concepts of Genetics (11th Edition)

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