Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 8.4, Problem 1TYK
Summary Introduction
Introduction:
The steroid hormones are the biochemical compounds that are formed from cholesterol and are hydrophobic in nature. The steroid hormones are typically the corticoids that include mineralocorticoids, glucocorticoids, and sex corticoids. The examples include testosterone, estrogen, and progesterone.
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A patient is prescribed drug for the treatment of his prostate cancer that blocks testosterone from binding to its intracellular receptor. Which of the following drugs has this mechanism of action?
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Place the following steps (showing how a steroid hormone changes the activities of its target cells) in order of what happens first, second, third, fourth, and last. Refer to image.
The hormone-receptor complex enters the nucleus of the cell and binds to the DNA.
The steroid hormone passes through the cell membrane.
The hormone attaches to a receptor in the cytoplasm, forming a hormone-receptor complex.
A gene in the DNA is activated, and transcription and translation take place.
Proteins that alter the cell′s activities, such as enzymes, are made.
2. Place the following steps (showing how a hydrophilic hormone changes the activities of its target cells) in order of what happens first, second, third, and last. Refer to image.
The activity of the target cell is changed by the final enzyme in the cascade.
The second messenger activates or deactivates certain enzymes in a cascade fashion.
A second messenger is activated.
Hormone binds to a receptor protein.
In a breast cancer patient whose tumor cells express large amounts of estrogen receptors and are therefore very sensitive to estradiol, which of these drugs will be very effective in reducing plasma levels of estradiol and consequently the breast tumor growth?
Group of answer choices
Letrozole
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Megestrol
Chapter 8 Solutions
Principles of Biology
Ch. 8.1 - What is the signaling molecule in this example?Ch. 8.1 - Prob. 2CCCh. 8.1 - Prob. 3CCCh. 8.1 - A general reason for cell signaling is to respond...Ch. 8.1 - Prob. 2TYKCh. 8.1 - Prob. 3TYKCh. 8.2 - Prob. 1BCCh. 8.2 - Prob. 1TYKCh. 8.2 - Prob. 2TYKCh. 8.3 - Prob. 1CC
Ch. 8.3 - What has to happen for the a and subunits of the...Ch. 8.3 - Prob. 1TYKCh. 8.3 - After a G-protein-coupled receptor is activated,...Ch. 8.4 - Prob. 1TYKCh. 8.5 - Look ahead to Figures 13.9 and, in particular,...Ch. 8.5 - Prob. 1TYKCh. 8.5 - Prob. 2TYKCh. 8.6 - Prob. 1CCCh. 8.6 - Prob. 2CCCh. 8.6 - Prob. 3CCCh. 8.6 - Prob. 1TYKCh. 8.6 - Prob. 2TYKCh. 8 - Prob. 1TYCh. 8 - Prob. 2TYCh. 8 - Prob. 3TYCh. 8 - Prob. 4TYCh. 8 - Which of the following is not an example of a cell...Ch. 8 - Prob. 6TYCh. 8 - The EGF receptor functions as a receptor tyrosine...Ch. 8 - Prob. 8TYCh. 8 - Prob. 9TYCh. 8 - The benefit of second messengers in signal...Ch. 8 - Prob. 1CCQCh. 8 - Prob. 2CCQCh. 8 - Prob. 3CCQCh. 8 - Discuss and compare several different types of...Ch. 8 - Prob. 2CBQ
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- Which of the statements is/are incorrect for hormones? 1) Hormones are non-nutrient chemicals serving as intercellular messengers. 2) Hormones are molecules of low molecular weight and are produced in traces. 3) Hormones give energy and also effect metabolism and growth activities of target cells. 4) Many hormones are produced in inactive form.arrow_forwardUnder in vivo conditions, chronic treatment with a noncompetitive antagonist may lead to the up-regulation of the targeted receptor over time. True False Cytokines are peptides that are generally made in advance by specific types of cells, stored in vesicles, and act as autocrine or paracrine factors. True False Thyroid hormone is stored in an extracellular compartment. True Falsearrow_forwardDescribe intracellular receptors, using estrogen receptors as anexamplearrow_forward
- Which of the following statements about hormones is correct? O steroid hormones are water soluble O epinephrine, norepinephrine, and dopamine are all catecholamines O receptor molecules of water soluble hormones are usually cell membrane proteins O water soluble hormones act on target cells by altering gene expression O Amine hormones are all lipid soluble O receptor molecules of lipid soluble hormones are usually in the cytoplasm or nucleus, but can also be in the cell membrane O insulin, growth hormone, and ecdysone are all examples of peptide hormonesarrow_forwardExplain how mutations in the following proteins might result in either loss of responsiveness to a given hormone or production of a continuous signal even in the absence of the hormone: a mutation in the regulatory (R) subunit of cAMP-dependent protein kinase, making R incapable of binding to the catalytic (C) subunitarrow_forwardProvide annotated structure image/diagram of the EPH RECEPTOR B2 (EPHB2). Giving the ligand bidning sites.arrow_forward
- Which of the following best explains how hormone antagonists work? Multiple Choice By flooding the cancerous cells with hormones By blocking actions of hormones that the cancer cells need to function By competing with uracil or cytarabine and metabolizing the nutrients required for hormone production By inhibiting folic acid, which is essential for blood cell and hormone productionarrow_forwardList the anterior pituitary hormones that have the alpha subunit in common. Which other hormone shares the same alpha subunit? Describe in 1-2 sentences if you had to design an immunoassay to detect each of those hormones, how you would ensure that your assay is specific for your hormone of interest?arrow_forwardIn addition to carrying information between the brain and the peripheral nervous system, the spinal cord also functions 11 to coordinate fine movements in skeletal muscles to carry impulses which control heart and breathing rates as the control center for some reflex actions as the control center for production of digestive secretions Hormones move through the circulatory system and come in contact with all tissues in the body. Whether a group of cells is targeted by a particular hormone depends upon ↑ #3 O O @ 2@ 3 £ the location of the cells in relation to the gland that produces the hormone the presence of appropriate receptor proteins on the cell membranes whether the cells are actively dividing and growing whether the cells are also being stimulated by the nervous system с 54 $ 4¢ O M % 5 ¤ A 31 acer Oll 6¬ ? & 71 O * 2 9 xarrow_forward
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