Campbell Biology in Focus
Campbell Biology in Focus
3rd Edition
ISBN: 9780134710679
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Rebecca Orr
Publisher: PEARSON
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Chapter 2.1, Problem 2CC
Summary Introduction

To describe:

The effect of iron deficiency in humans which is responsible for carrying oxygen in red blood cells.

Introduction:

Trace elements or minerals are those elements that are required by the body of an organism in small amount. These include iron, manganese, copper, molybdenum, zinc, boron, chlorine, nickel, iodine, selenium, chromium, silicon, vanadium, fluoride, lead cadmium, mercury, arsenic, aluminum. They are present in small amount but are important for the growth and development of body.

Some of these trace elements are used as a catalyst for enzymatic reactions. Trace elements are toxic if it is consumed in higher quantity. Trace elements are of two types essential and non essential. Essential trace elements are those which are required for the growth and development while non essential elements are those that are present in the body but are not required for growth and development.

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pO2 in tissues p02 in lungs 1.00 Oxygen-binding curves for normal Normal Hb hemoglobin, 50% carboxyhemoglobin, and hemoglobin from 0.8 an anemic individual. 0.6 Y 50% COHB 0.4- Anemic individual 0.2 4 8 12 pO2 (kPa) Box 5-1 Figure 2 Lehninger Principles of Biochemistry, Seventh Edition O 2017 W. H. Freeman and Company r aye i UIE I. Answer the following questions. Do not forget the units. 1) From the binding curve for normal Hb shown above, what is the Ka of normal hemoglobin?
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3. When muscles are more active physiological conditions change to affect oxygen binding to Hemoglobin.  Briefly describe the changes that occur and why this affects hemoglobin function.  Draw the shifted curve on the graph above. A. What physiological conditions change during exercise (levels of what molecules are increasing/decreasing)?   B. How do these molecules directly affect Hb’s structure ? What interactions does this stabilize ? C. How do these interactions affect the affinity of Hb for O2? How would this affect the binding curve for Hb? Draw on the graph provided.  D. How will this shift in the binding curve affect the function of Hemoglobin ?  E.Where does the physiological pO2 in the tissues fall on the O2 binding curve ? In the lungs ? Why is this physiologically important?

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