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Why is critical thinking and evidence-based decision-making important as a DNP-FNP?
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- What does SNP stand for? How do SNPs cause disease?What can your personal genome tell you about your genetic risk factors?A pilot small scale association study involving 20 subjects and two candidate SNP‘s has the results shown in the table below which SNP (s) are/is likely associated with the disease understudy?
- How might we, as epidemiologists, increase the validity of genetic studies? What recommendations do you have (assume that you have all of the resources you'd need to implement these changes)?How might the Hardy Weinberg relationship be used to evaluate a new SNP genotyping technology using multiple individuals from a population? Group of answer choices a)If genotypes match the reference genome, the technology is sound. Otherwise, the technology may have problems accurately calling SNPs. b)If observed phenotypes follow Hardy Weinberg, the technology is sound. Otherwise, the technology may have problems accurately calling SNPs. c)If genotypes and allele frequencies follow Hardy Weinberg, the technology is sound. Otherwise, the technology may have problems accurately calling SNPs. d)None of the aboveIn terms of eugenics/genetic control, what type of argument could be made in favor of negative (or therapeutic) eugenics? What are some concerns? What type of argument could be made for positive (or enhancement) eugenics? What are some concerns? (It should be clear that you have read and considered the arguments that Sandel and Julian Savulescu have made on genetic control.)
- What are the different genetic markers that genome-wide association studies (GWAS) employ? How can scientists use this data to calculate the disease risk associated with each variation?. BMI (Body mass index) is the ratio mass in kilograms to the square of height in kilograms Between 18 and 25 is normal. Below 18 is low and above 25 is high. You are looking for SNPS that correlate with low BMI. You look at a number of individuals and look at their BMIS And look at several SNPS. Which SNP best correlates with low BMI? 1-1 1-2 2-1 2-2 BMI 25 16 31 2-3 2-4 2-5 3-5 3-6 15 26 SNP1 A A A A T 3,7 4,5 3 2,3 7 4,9 4 4,7 SNP2 B 3 G 2,6 2,6 3,6 2,3 3,6 3,4 4,6 3 G G C C What is exome sequencing? Give an application. OOOO D 5 The above pedigree is an autosomal dominant trait. You are trying to identify the gene responsible, so you start by looking at some variable markers to determine which ones might map near the disease gene. You look at 6 markers (A-F). The numbers refer to sizes in 1000 o bases. Individuals in bold have the trait Which marker (A-F) is most likely to be associated w the trait Individual A 2 SNP3 T T T C C C 1,5 2,4 3,7 1,4 2,5 1,2 4,6 2,6 1,4 SNP4 D 1,6 4,5…Cystic fibrosis (CF) is a genetic disorder affecting a number of organs, including the lung airways, pancreas, and sweat glands. Mutations in both copies of the CFTR gene causes cystic fibrosis. Imagine that you have sweat gland samples from several Cystic Fibrosis patients (A-C) with unknown mutations in CFTR. You also have normal (+) sweat gland sample to use as a positive control. А В С А В С Choose which mutation would explain the RNA and protein results in A, B, & C: 1. Promoter/Regulatory mutation 2. Silent mutation 3. Missense mutation 4. Deletion mutation 5. Splice site mutation 6. Nonsense mutation RNA gel Protein gel
- What is the one main advantage of the whole-genome shotgun strategy over the hierarchical approach?What causes SNPs?What is preimplantation genetic testing? Give an example of a condition screened for? Do you agree with preimplantation screening and what are some of the ethical concerns surrounding the practice?