What is the name of the fibronectin receptor that cells use to stick to the fibronectin present in the ECM? Interphasin Adaptin Cadherin Integrin
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- Members of the integrin family are the major cell surface receptors for many ECM proteins such as fibronectin. In experimental studies, single integrin heterodimers have been found to assume more than one structural conformation. Describe the relationship between integrin structures and their activities.What is transmitter gated ion channels? What is their purpose?What do you understand by Fibronectin protein?
- The Structure of the acetylcholine receptor is shown below: A. Knowing the amino acid sequence of this protein, what tool would you use to identify the membrane-spanning region? Explain how it works.Buckeyium is a medication that binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume glycine is already bonded and magnesium isn't inhibiting the NMDAR ion channel. Buckeyium would be regarded a poison if the channel did not open as a consequence of its binding.The drug Buckeyium binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume that glycine is already bound, and that magnesium is not blocking the NMDAR ion channel. If the channel does not open as a result of Buckeyium binding than Buckeyium would be considered a
- Inhibitors of acetylcholinesterase, such as edrophonium, are used to treat Alzheimer’s disease. The substrate for acetylcholinesterase is acetylcholine. Structures are attached. What kind of inhibitor is edrophonium? Explain. Can inhibition by edrophonium be overcome in vitro by increasing the substrate concentration? Explain. Does this inhibitor bind reversibly or irreversibly to the enzyme? Explain.A3 KcsA K+ ion channel has their selectivity filer arranged as amino acid "TVGYG", so it can only binding with K+ ion, if this amino acid arrangement changed to "TVGDG", it can also select Na+ ion. why?Explain why this is not true about ion channel receptors; It forms hydrophobic hollow because it is a membrane bound receptor.
- Estimate the binding affi nity of a ligand for its receptor from the followingdata:After establishing the importance of cGMP in the signaling pathway of the photoreceptor cells, the researchers wish to identify the exact target of cGMP. The researchers suspect that cGMP binds to an ion channel, causing the observed change in the membrane potential between the dark and the light conditions but they are not sure which one. The researchers determine the movement of three different ions (sodium, chloride and potassium) as a function of their respective electrochemical gradient across the plasma membrane: ● Sodium tends to enter the cell Chloride tends to enter the cell Potassium tends to leave the cell The researchers therefore propose three simple hypotheses for the effect of cGMP on the membrane potential of the rod photoreceptor cell: ● Hypothesis A: CGMP binds to a sodium-channel, that opens and lets sodium ions diffuse inside the cell. Hypothesis B: cGMP binds to a chloride-channel, that opens and lets loride ions diffuse inside the cell. Hypothesis C: cGMP binds to…You have synthesized an oligopeptide containing an RGD motif surrounded by other amino acids. What is the effect of this peptide when added to a fibroblast cell culture grown on a layer of fibronectin adsorbed to the tissue culture dish? Why does this happen?