Buckeyium is a medication that binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume glycine is already bonded and magnesium isn't inhibiting the NMDAR ion channel. Buckeyium would be regarded a poison if the channel did not open as a consequence of its binding.
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Buckeyium is a medication that binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume glycine is already bonded and magnesium isn't inhibiting the NMDAR ion channel.
Buckeyium would be regarded a poison if the channel did not open as a consequence of its binding.
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- The drug Buckeyium binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume that glycine is already bound, and that magnesium is not blocking the NMDAR ion channel. If the channel does not open as a result of Buckeyium binding than Buckeyium would be considered aThe Structure of the acetylcholine receptor is shown below: A. Knowing the amino acid sequence of this protein, what tool would you use to identify the membrane-spanning region? Explain how it works.Estimate the binding affi nity of a ligand for its receptor from the followingdata:
- The NMDA receptor I/V curve is nonlinear, why? What about the GluA2-containing AMPA receptor I/V curve? Draw both under normal physiological conditions. In addition, explain what happens for the NMDA receptor I/V curve when you lower the magnesium concentration.compare the structures of the peptide neurotransmitters Met-enkephalin and Leu-enkephalinName three features common to the activation of cytokine receptors and receptor tyrosine kinases. Name one difference with respect to the enzyme activity of these receptors.
- Ethanol is unusual in that it is freely soluble in both water and lipids. Thus, it has access to all regions of the highly vascularized brain. Although the molecular basis of ethanol action in the brain is not clear, ethanol evidently influences a number of neurotransmitter receptors and ion channels. Suggest a biochemical explanation for the diverse effects of ethanol.Unlike dopamine, levodopa can cross the blood brain barrier (BBB). Which of the following statements best describes the reasoning Donm sond но. NH2 но, HO. NH2 но но Dopamine (log P 0.85) Levodopa (log P-0.22) The physicochemical properties of levodopa and its partial facilitated transport by neutral amino acid transporters can explain the ability of levodopa to cross the BBB The lower partition coefficient (log P) of levodopa indicates the molecule is more hydrophobic than dopamine, and therefore better able to cross the B88 Unlike dopamine, levodopa is not metabolized in the periphery, and therefore more circulating drug is avallable for transport across the BBB. OLevodopa itself cannot cross the BBB, and must be coadministered with carbidopa, which enables its BBB transport. Moving to another question will save this response.Inhibitors of acetylcholinesterase, such as edrophonium, are used to treat Alzheimer’s disease. The substrate for acetylcholinesterase is acetylcholine. Structures are attached. What kind of inhibitor is edrophonium? Explain. Can inhibition by edrophonium be overcome in vitro by increasing the substrate concentration? Explain. Does this inhibitor bind reversibly or irreversibly to the enzyme? Explain.
- The top panel (a) of this figure shows the graded potential change (far right, upper, electrical trace) that results from ligand binding to the ligand gated Na+ channel. The bottom panel of this figure (b) shows a graded potential change (far right, lower, electrical trace) that results from ligand binding to a ligand gated Cl- channel. From this trace you know (Vm = -70 mV) 1. ECl- is -70 mV 2. ECl- is more negative than -70 mV (i.e., -80 mV) 3. ECl- is more positive than -70 mV (i.e., -60 mV)Organophosphate poisoning is a result of excess acetylcholine at different nerves and receptors in the body because acetylcholinesterase is blocked. Please provide rational to explain how the binding of organophosphate with serine in the acetylcholinesterase enzyme leads to excess accumulation of acetylcholine.The drug Buckeyium binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume that glycine is already bound, and that magnesium is not blocking the NMDAR ion channel. If the channel does not open as a result of Buckeyium binding than Buckeyium would be considered a ____________. A. Indirect Antagonist B. Positive Allosteric Modulator C. Negative Allosteric Modulator D. None of the choice options are correct E. Non-Competitive Antagonist