The Warburg effect is where tumor cells preferentially catabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis), whereas normal cells preferentially catabolize glucose to carbon dioxide (oxidative phosphorylation). Treatment of tumor cells with the lactate dehydrogenase inhibitor NCI-737 blocks ATP production. Which of the following statements about NCI-737 treated tumor cells are MOST correct? 1) AGglycolysis is negative 2) AGglycolysis is positive 3) AG" for glycolysis is negative 4) AG" for glycolysis is positive 5) NAD+/NADH decreases 6) NAD+/NADH increases 1, 4, 6
The Warburg effect is where tumor cells preferentially catabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis), whereas normal cells preferentially catabolize glucose to carbon dioxide (oxidative phosphorylation). Treatment of tumor cells with the lactate dehydrogenase inhibitor NCI-737 blocks ATP production. Which of the following statements about NCI-737 treated tumor cells are MOST correct? 1) AGglycolysis is negative 2) AGglycolysis is positive 3) AG" for glycolysis is negative 4) AG" for glycolysis is positive 5) NAD+/NADH decreases 6) NAD+/NADH increases 1, 4, 6
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:The Warburg effect is where tumor cells preferentially catabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis),
whereas normal cells preferentially catabolize glucose to carbon dioxide (oxidative phosphorylation). Treatment of tumor cells with the
lactate dehydrogenase inhibitor NCI-737 blocks ATP production. Which of the following statements about NCI-737 treated tumor cells are
MOST correct?
1) AGglycolysis is negative
2) AGglycolysis is positive
3) AG" for glycolysis is negative
4) AG" for glycolysis is positive
5) NAD+/NADH decreases
6) NAD+/NADH increases
1, 4, 6
1, 3, 5
2, 4, 6
2, 3, 6
2, 3, 5
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