In acute lymphoblastic leukemia, the cancerous white blood cells typically lack the enzyme asparagine synthetase. Why is the administration of asparaginase an eff ective therapy for this type of cancer?

Q: What is the mechanism of chymotrypsin catalysed by enzymes without cofactors?

A: CHYMOTRYPSIN is a digestive enzyme of pancreatic juice acting on the duodenum where it performs…

Q: The enzyme useful in the treatment of leukemia is which of the following? a. alpha-chymotrypsin b.…

A: Leukemia is the cancer of blood and bone marrow. It begins in the developing blood cells in the bone…

Q: A. Elastase is activated by trypsin B. Trypsinisactivatedbyelastase Which statement is correct?

A: Note- we are supposed to answer one question according to our guidelines.  Please repost other…

Q: As a cell makes the transition from normal to malignant growth, there is increased dependency on…

A: Km value is numerically equal to substrate concentration at which half of the enzyme molecules are…

Q: rostaglandin-endoperoxide synthase 2, also known as cyclooxygenase- or COX-2, is an enzyme that in…

A: Prostaglandins directly act upon nerve endings to induce pain. They may also speed up the process of…

Q: Mucins found on adenocarcinoma cells carry O-glycans terminated with sialic acids (such as the…

A: Mucins are proteoglycans with many carbohydrate moieties glycosylated to the protein. The type of…

Q: The serine residues in acetyl CoA carboxylase that are the target of the AMP-activated protein…

A: Fatty acids are carboxylic acids that contain a long aliphatic chain that could be either branched…

Q: Can you please elaborate why blocking the inhibitory G protein from deactivating adenylate cyclase…

A: The inhibitory G protein has a role in the body’s biochemistry, including in the peripheral regions…

Q: Homocystinuria is caused by a defect in cystathionine beta-synthase (or 13-synthase), which leads to…

A: Homocystinuria is an uncommon hereditary disorder that can be fatal. It signifies that the amino…

Q: Hydroxyurea has been shown to increase the expression of fetal hemoglobin in adult red blood cells,…

A: Sickle cell anemia is the disorder in which abnormality in oxygen carrying hemoglobin present in red…

Q: Proteolytic enzymes are produced in an inactive form. What, if any, benefit might that have?

A: The biocatalysts that catalyze the protein's breakdown into smaller polypeptides or amino acids by…

Q: In the blood coagulation pathway, several proenzymes are activated by unique proteolytic cleavage…

A: Blood Coagulation is a series through which the blood clotting enzymes are activated in order to…

Q: Cells defective in thymidylate synthase are able to undergo cell division if methotrexate and…

A: Thymidine, also known as deoxythymidine, is defined as a deoxynucleoside comprised of the pyrimidine…

Q: Tumor cells often lack an extensive capillary network and must function under conditions of limited…

A: Tumor cells: These are damaged or abnormal cells that multiply in numbers, resisting death.

Q: effects of ketosis in the body

A: Ketosis can be defined as the process that occurs when our body does not have enough carbohydrates…

Q: Tumor cells, which tend to grow rapidly, typically express high levels of the glycolytic enzymes.…

A: Enzyme is a catalytic molecule that increases the rate of any chemical reaction without being used…

Q: In the liver, the relative activity of ornithine transcarbamylase is high, that of argininosuccinate…

A: Ornithine transcarbamylase is the enzyme that catalyzes the conversion of carbamyl phosphate and…

Q: Name the glycolytic enzymes that are allostericallyregulated.

A: Glycolysis is the cytoplasmic pathway which breaks down glucose into two three-carbon compounds and…

Q: How is Pyruvate Kinase Deficiency (PKD) inherited? What gene is responsible for the expression of…

A: Pyruvate kinase is an enzyme that regulates cell metabolism by catalysing the conversion of…

Q: How can a person suffering from Adenosine Deaminase deficiency be cured?

A: Introduction In this question we will discuss about how a person suffering from Adenosine Deaminase…

Q: Phosphorylation of CFTR by ____________ results in Cl− and HCO-3 secretion into the intestinal…

A: CFTR belongs to the ATP-binding cassette (ABC) transporter superfamily. It helps to maintain the…

Q: would you expect an inhibitor of lactate dehydrogenase to be an effective anti-cancer drug? Why or…

A: Lactate dehydrogenase is the enzyme which catalytically helps in the conversion of lactate to…

Q: What is the purpose of having ACP as a distinct activating group for fatty-acid synthesis?

A: Acyl carrier protein (ACP) is an essential part of multienzyme complex known as fatty acid synthase…

Q: Pyruvate dehydrogenase kinase is a deffected enzyme and it is the connection between the alteration…

A: Hi! Thanks for your question. But as you have posted multiple questions, I am answering the first…

Q: It has been shown that pathogenic microbes that invade and reside within macrophages require the…

A: The immune system of the body protects the organisms from the harmful pathogen. The differenet…

Q: CTP inhibits ATCase; however, the inhibition is not complete. Can you suggest another molecule that…

A: Aspartate (ATCase) carbamoyltransferase is an enzyme, which is involved in pyrimidine biosynthesis.…

Q: Leukemia is a neoplastic (cancerous) proliferation of white blood cells. Clinicians are currently…

A: Cancer is a basic abnormality of cell division. This abnormal change is brought by various factors;…

Q: Explain the regulatory processes of purine synthesis that would result in an increase in the…

A: de novo synthesis of purine begins with simple starting materials such as amino acids and…

Q: Why are hemoglobin proteins made only in red blood cells and insulin proteins only in certain…

A: Genes are the hereditary components that are located on the chromosomes. They can be passed on from…

Q: —Hemophilia B, an X-linked genetic disorder which highly affects males, is a condition in which…

A: Hemophilia A and hemophilia B are X linked recessive genetic disorder which generally affects male.…

Q: Lysozyme is a catalytic enzyme that cleaves NAG-NAM units in the bacte- rial cell wall, and is found…

A: Lysozyme is a naturally occurring enzyme found in secretions such as tears, saliva and milk. It…

Q: Which glucose transporter is affected by the increased AKT signaling in tumor cells?

A: Tumour cells have a high metabolic turnover. Hence they need high amounts of glucose to sustain high…

Q: Why do protease-supplying cells of the stomachand of the pancreas make onlyprecursors of the…

A: The organs of the digestive tract secrete several digestive enzymes to support the chemical…

Q: The pyruvate kinase isozyme in cancerous cells has low activity compared to the isozymes in other…

A: Introduction: Pyruvate kinase is a protein that catalyzes the change of phosphoenolpyruvate and ADP…

Q: Normal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells…

A: Methotrexate is a chemotherapy agent which is used to treat cancer, autoimmune diseases, ectopic…

Q: . Leukemia is a neoplastic (cancerous) proliferation of white blood cells. Clinicians are currently…

A: Leukemia is cancer of blood and bone marrow. Bone marrow located in the spongy portions of the…

Q: Pyruvate dehydrogenase kinase is a deffected enzyme and it is the connection between the alteration…

A: Pyruvate, the end product of glycolysis, in the cytoplasm, undergoes further oxidation, in the…

Q: Why are cancer cells especially sensitive to inhibitors of TMP synthesis?

A: Thymidylate synthase is an enzyme that is responsible for conversion of deoxyuridine monophosphate…

Q: The end products of tryptophan degradation are acetyl CoA and acetoacetyl CoA, yet tryptophan is a…

A: Introduction The catabolism of carbon skeletons of amino acids results in seven metabolic products.…

Q: Explain the function of histidine 57 in the mechanism of chymotrypsin.

A: The function of Histidine 57 in the mechanism of chymotrypsin can be described in the following way:…

Q: What selective advantage does aerobic glycolysis offer the tumor over the energetically more…

A: Glucose is used by most of the body cells to obtain energy in the form of ATP. The level of glucose…

Q: explain whether lactase enzyme is secreted as a zymogen requiring activation or not. If it is,…

A: The lactase enzyme is a beta-galactosidase that hydrolyses lactose to glucose and galactose. A…

Q: Fluorouracil is a structural analogue of thymine. The fluorine promotes enolization. How is this…

A: Introduction The chemotherapeutic drug fluorouracil (5-FU) is used to treat cancer. It is used to…

Q: Explain how the pKa for histidine 57 is important to its role in the mechanism of chymotrypsin…

A: Chymotrypsin is a digestive enzyme found in pancreatic juice that conducts proteolysis, or the…

Q: To examine: Whether the statement "protein tyrosine phosphatases display exquisite specificity for…

A: Protein tyrosine phosphatases shows exquisite specificity for their substrates.

Metabolic pathways

Metabolism is defined as the group of life-supporting, enzyme-mediated chemical reactions in organisms. A metabolic pathway is a set of these chemical reactions that involve anabolism (synthesis of complex biomolecules) and catabolism (breakdown of biomolecules into small molecules) that occur inside a cell. Metabolites are the reacting substances, products, and intermediate substances of an enzymatic process that are altered by a series of chemical events catalyzed by enzymes.