Q5. A sh mutant called shXS is isolated that produces a truncated polypeptide of only 6 AAs in length. Describe a single basepair DNA change that would lead to this truncated version of the protein. Multiple options are possible (100 words max.) [10%] Q6. A single basepair mutant in the sh gene (shNH) was found to have an A mutated into a G at the 3rd position of the 3rd codon of the sh gene: WILD-TYPE: 5’-tataatgggcttaacaATGAGTAAAAGAGGTCCTTTACTCCGGTATCACCAATAGaaatattatttaa-3’ Mutant shNH 5’-tataatgggcttaacaATGAGTAAGAGAGGTCCTTTACTCCGGTATCACCAATAGaaatattatttaa-3’ What are the functional consequences of this mutation for the Sh protein? Motivate your answer (100 words max.) [10%]
Q5. A sh mutant called shXS is isolated that produces a truncated polypeptide of only 6 AAs in length. Describe a single basepair DNA change that would lead to this truncated version of the protein. Multiple options are possible (100 words max.) [10%] Q6. A single basepair mutant in the sh gene (shNH) was found to have an A mutated into a G at the 3rd position of the 3rd codon of the sh gene: WILD-TYPE: 5’-tataatgggcttaacaATGAGTAAAAGAGGTCCTTTACTCCGGTATCACCAATAGaaatattatttaa-3’ Mutant shNH 5’-tataatgggcttaacaATGAGTAAGAGAGGTCCTTTACTCCGGTATCACCAATAGaaatattatttaa-3’ What are the functional consequences of this mutation for the Sh protein? Motivate your answer (100 words max.) [10%]
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter15: Genes And Proteins
Section: Chapter Questions
Problem 29CTQ: A normal mRNA that reads 5’ - UGCCAUGGUAAUAACACAUGAGGCCUGAAC- 3’ has an insertion mutation that...
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Question
Q5. A sh mutant called shXS is isolated that produces a truncated polypeptide of only 6 AAs in length. Describe a single basepair DNA change that would lead to this truncated version of the protein. Multiple options are possible (100 words max.) [10%]
Q6. A single basepair mutant in the sh gene (shNH) was found to have an A mutated into a G at the 3rd position of the 3rd codon of the sh gene:
WILD-TYPE:
5’-tataatgggcttaacaATGAGTAAAAGAGGTCCTTTACTCCGGTATCACCAATAGaaatattatttaa-3’
Mutant shNH
5’-tataatgggcttaacaATGAGTAAGAGAGGTCCTTTACTCCGGTATCACCAATAGaaatattatttaa-3’
What are the functional consequences of this mutation for the Sh protein? Motivate your answer (100 words max.) [10%]
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