The mechanism by which DNA is licensed to replicate only once during each S phase involves ORC and helicase loaders binding to geminin. MCM proteins binding to geminin after replication ORC and helicase loaders being phosphorylated. MCM proteins binding only to replicated DNA. MCM proteins binding only to CEN DNA. IncorrectThe mechanism by which DNA is licensed to replicate only once during each S phase involvesORC and helicase loaders binding to geminin.MCM proteins binding to geminin after replicationORC and helicase loaders being phosphorylated.MCM proteins binding only to replicated DNA.MCM proteins binding only to CEN DNA.0/1 pts

Option A: This option is incorrect because ORC and helicase loaders do not bind to geminin during…

Incorrect The mechanism by which DNA is licensed to replicate only once during each S phase involves ORC and helicase loaders binding to geminin. MCM proteins binding to geminin after replication ORC and helicase loaders being phosphorylated. MCM proteins binding only to replicated DNA. MCM proteins binding only to CEN DNA. 0/1 pts

Incorrect The mechanism by which DNA is licensed to replicate only once during each S phase involves ORC and helicase loaders binding to geminin. MCM proteins binding to geminin after replication ORC and helicase loaders being phosphorylated. MCM proteins binding only to replicated DNA. MCM proteins binding only to CEN DNA. 0/1 pts

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 22P

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(Select one answer from each dropdown menu:) DNA replication uses as templates to make an Choose one: GAUDIe copy of a DNA molecule. complementa DNA replication is known exact molecule has 1 original stChoose one: 1 new strand of DNA. This ensures the conservation of genetic information. because each new DNA (Select one answer from each dropdown menu: ) In mitosis, the goal is to get cells that are genetically Choose one: This process is used to make Choose one: Match the following Mitosis stages to what happens Prophase Metaphase Anaphase Telophase a. sister chromatids pull apart to opposite ends of cell b. chromosomes line up at the equator of the cell c. Nuclear envelope reforms and chromosome loosen d. nuclear envelope disappears, chromosoměs a. condense During what phase does the cytoplasm divide? (Select one answer from dropdown menu:) Choose one: (Select one answer from each dropdown menu and fill in the blank:) In meiosis, the goal is to get cells that are genetically Choose…
If a mutation occurred that prevented single stranded binding proteins from binding, the result would be: O Replication would not be initiated O DNA would be synthesized on the leading strand, but not the lagging strand Replicating would be initiated, DNA would unwind, RNA primers would be laid down, but DNA polymerase would not bind O The newly synthesized RNA would not be able to leave the DNA template Replication would be initiated, but RNA primers would not anneal to the DNA
Which of the following statements is NOT TRUE about genomic DNA replication? O A DNA replication begins at the origin of replication and proceeds bi-directionally O B. New nucleotides can be added by the DNA polymerase only to the 3 end of the growing strand O. Synthesis of new DNA is catalyzed by the enzymes called DNA polymerases OD. DNA replication is semi-conservative OE. DNA replication proceeds continuously on both parental DNA strands.
Which of the following are true about bacterial DNA replication compared to DNA replication in humans (eukaryotes) (select all that apply) Bacteria can replicate their entire genome more quickly than human cells can Bacteria DNA replication uses more types of DNA polymerase than human cells do Bacteria can replicate DNA continuously, but eukaryotes wait for the S phase of the cell cycle Bacterial DNA replication does not require helicases, because the chromosome is circular DNA sequence where replication initiates are rich in A's and T's in eukaryotes, but not in bacteria Bacteria have more origins of replication than human chromosomes do
Discuss DNA replication of prokaryotes and please mention all of the enzymes and components listed below. DNA Primase – DNA directed “RNA Pol” which inserts nucleoside triphosphates (NTPs) Primers are oligonucleotides; priming process is the formation of primers DNA Helicase – separates the DNA in advance of the replication fork (in E. coli DNA Helicase II); binds at AT-rich region of DNA; ATP then binds the helicase Single-stranded DNA-binding Protein (SSBP) – no enzymatic activity; does not consume ATP Topoisomerase – alter the supercoiling of double-stranded DNA DNA Ligase – nicking of strands done for replication to continue Okazaki fragments DNA Polymerase – removes primer via 5’ to 3’ exonuclease activity; comes again for 5’ to 3’ polymerization activity (closes the gap between Okazaki fragments) Prokaryotes DNA Pol I – auxiliary enzyme to DNA Pol III; repairs damage; capable of excising pyrimidine dimers; polymerization via single active site that can bind all 4 dNTPs;…
During DNA replication, one of the new strands of DNA is synthesized continuously, while the other is synthesized as a number of separate fragments of DNA that are subsequently linked by DNA ligase. This is because O replication starts at many points on the chromosome RNA primers only anneal to one of the parental strands of DNA one of the parental strands is unwound slower than the other by helicase DNA polymerase III only synthesizes DNA in the 5' - 3' direction
Labeling DNA Replication Directions: Drag the lahels from the left tn corrary derti theinats of ar=rlicating strandarA 24 Newly Created Strand of ONA Replication Carke Original DNA Strand Replication Direction of Origin of Replication Directions: Bolow is a more in-depth look at a replication bubble. A.l of the psrts are still tne came, but
How does DNA replication occur in a precise manner to ensure that identical genetic information is put into the new chromatid? See Figures 8.12 and 8.13. FIGURE 8.12 In DNA replication, the two polynucleotide strands uncoil, and each is a template for synthesizing a new strand. A replicated DNA molecule contains one new strand and one old strand. This mechanism is called semiconservative replication. FIGURE 8.13 A close-up look at the process of DNA replication. (a) As the strands uncoil, bases are added to the newly synthesized strand by complementary base pairing with bases in the template strand. The new bases are linked together by DNA polymerase. (b) DNA synthesis can proceed only in the 5 3 direction; newly synthesized DNA on one template strand is made in short segments and linked together by the enzyme DNA ligase.
Which of the following statements is TRUE? Synthesis of the lagging strand requires more DNA helicase enzymes than synthesis of the leading strand. The lagging strand is synthesized in a semiconservative fashion while the leading strand is synthesized in a conservative fashion. The leading strand is replicated continuously for the entire length of the chromosome, e.g. while the lagging strand has multiple origins of replication The lagging strand has a higher mutation rate than the leading strand. None of the answers are true.
Why are Gyrase inhibitors good antibiotics to use therapeutically? DNA Gyrase is required by prokaryotes, but not eukaryotes, to complete chromosomal replication so it's a good target to inhibit. O DNA Gyrase is required by eukaryotes, but not prokaryotes, to complete chromosomal replication so it's a good target to inhibit. It's impossible to develop resistance against Gyrase inhibitors so they are always effective. O DNA Gyrase is required by both prokaryotes and eukaryotes to complete chromosomal replication so it's a good target to inhibit.
Which of the following statements about DNA replication is correct? Group of answer choices the leading strand is replicated continuously, while the lagging strand is replicated discontinuously on the leading strand, the new nucleotides are added only to the 5' end of the nucleotide chain on the lagging strand, the new nucleotides are added only to the 5' end of the nucleotide chain DNA polymerase works from 3'--> 5' only
Which of the following statements regarding DNA Synthesis at the ends of linear chromosomes is true? Because DNA polymerase has proofreading capablities, replication at the ends of linear chromosomes is usually error-free, and telomerase, an enzyme composed of both RNA and protein, simply ensures that any incorporated errors are corrected. O DNA synthesis at the ends of linear chromosomes is a problem also observed in prokaryotic cells. Ov. Cancer in humans is associated with a reduction in the activity of telomerase. y Telomerase, an enzyme composed of both RNA and protein. fünctions by cleaving the 3 overhangs that are left by DNA polymerase.