Discuss the interplay between genetics and environment in the development of cancer (it would be helpful to focus on one tumor suppressor/disease to narrow the scope of the discussion). Which factor (genetics or environment) is playing a larger role within your chosen context? Justify your argument.
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Discuss the interplay between genetics and environment in the development of cancer (it would be helpful to focus on one tumor suppressor/disease to narrow the scope of the discussion). Which factor (genetics or environment) is playing a larger role within your chosen context? Justify your argument.
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- A microarray is a technique used to develop a profile of the messenger RNA being transcribed by cells at a particular point in the life cycle of the cell. This allows the researcher to detect the expression of particular genes at a particular time. Microarrays have proven very useful in the detection of genes involved in certain types of cancer. If the product of a particular gene functions as a tumor suppressor, which piece of evidence do you think would be the most useful in the diagnosis of a cancer due to a nonsense mutation in this tumor-suppressor gene? (Hint: Don't worry about what a microarray is. Think about what you know about mitosis, cancer, and types of mutation.) O The tissue sample responds to treatment with a mitosis-promoting compound. O The tissue sample shows a high level of gene expression relative to a control (noncancerous) sample. O The mRNAs for the targeted tumor suppressor sequence are not being produced. O The mRNAs for cyclins and kinases show unusually high…Discussion: (1 or 2 paragraphs with your own opinion like how Circulating Tumor DNA as Biomarkers for Cancer Detection technology can be early detector of cancer)Which of the following effectively describes the situation of someone with an inherited predisposition to cancer such a familial adenomatous polyposis or BRCA-associated familial breast cancer? Choose all that apply Group of answer choices None of the other answers effectively describes the situation If they get malignant cancer, somatic mutations will not have been a factor Their cancer will most likely arise in their germ cells, not their somatic cells Most cells in their body contain multiple cancer-causing mutations Every cell of their body contains a gain-of-function allele of an oncogene Every cell of their body contains a defective, loss-of-function allele of a tumor suppressor gene
- There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressedStudies have shown that there are significant differences in cancer rates among different ethnic groups. For example, the Japanese have very high rates of colon cancer but very low rates of breast cancer. It has also been demonstrated that when members of low-risk ethnic groups move to high-risk areas, their cancer risks rise to those of the high-risk area. For example, Japanese who live in the United States, where the risk of breast cancer is high, have higher rates of breast cancer than do Japanese who live in Japan. What are some of the possible explanations for this phenomenon? What factors may explain why the Japanese have higher rates of colon cancer than do other ethnic groups?
- For many years, targeted therapies for cancer treatment continue to be developed, however more and more patients are developing resistance to targeted therapies. Discuss one mechanism of resistance to targeted therapies for cancer and provide an example of how might creatively combat it using clinical concepts.write a comprehensive, one-page position paper about your stand on the practice of stem cell therapy and genetic engineering. Consider the following guide questions in establishing your arguments: •Could the widespread use of gene therapy make society less accepting of people who are different? •Will genetic engineering permanently change our society?Which type of stem cell therapy may cause some ethical issues and may results in benign tumor? (Name only, no description required)
- during tumor progression, additional mutations occur within multiple cells of a tumor population, leading to multiple different clones of cells within that tumor. Some) but not all) clones may eventually metastasize, depending on the number and type of mutations that occur in those clones. true falseDescribe how you would analyze the data collected from a cancer program evaluation and which type or types of results would justify continuing the program.: The effects of DNA mutations within the p53 gene on the structure and function of the protein encoded by the gene. The essay should focus on the following discussion points: The normal functions of the p53 gene. Known mutations of the gene. The impact of mutations on the structure of the protein encoded by the gene. The impact of mutations on the function of the protein. Current therapeutic interventions that aim to address the impact of mutations on gene function