A microarray is a technique used to develop a profile of the messenger RNA being transcribed by cells at a particular point in the life cycle of the cell. This allows the researcher to detect the expression of particular genes at a particular time. Microarrays have proven very useful in the detection of genes involved in certain types of cancer. If the product of a particular gene functions as a tumor suppressor, which piece of evidence do you think would be the most useful in the diagnosis of a cancer due to a nonsense mutation in this tumor-suppressor gene? (Hint: Don't worry about what a microarray is. Think about what you know about mitosis, cancer, and types of mutation.) O The tissue sample responds to treatment with a mitosis-promoting compound. O The tissue sample shows a high level of gene expression relative to a control (noncancerous) sample. O The mRNAs for the targeted tumor suppressor sequence are not being produced. O The mRNAs for cyclins and kinases show unusually high levels of expression.

Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter16: Regulation Of Gene Expression
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A microarray is a technique used to develop a profile of the messenger RNA being transcribed by
cells at a particular point in the life cycle of the cell. This allows the researcher to detect the
expression of particular genes at a particular time. Microarrays have proven very useful in the
detection of genes involved in certain types of cancer. If the product of a particular gene functions
as a tumor suppressor, which piece of evidence do you think would be the most useful in the
diagnosis of a cancer due to a nonsense mutation in this tumor-suppressor gene? (Hint: Don't
worry about what a microarray is. Think about what you know about mitosis, cancer, and types of
mutation.)
O The tissue sample responds to treatment with a mitosis-promoting compound.
O The tissue sample shows a high level of gene expression relative to a control (noncancerous)
sample.
O The mRNAs for the targeted tumor suppressor sequence are not being produced.
O The mRNAs for cyclins and kinases show unusually high levels of expression.
Transcribed Image Text:A microarray is a technique used to develop a profile of the messenger RNA being transcribed by cells at a particular point in the life cycle of the cell. This allows the researcher to detect the expression of particular genes at a particular time. Microarrays have proven very useful in the detection of genes involved in certain types of cancer. If the product of a particular gene functions as a tumor suppressor, which piece of evidence do you think would be the most useful in the diagnosis of a cancer due to a nonsense mutation in this tumor-suppressor gene? (Hint: Don't worry about what a microarray is. Think about what you know about mitosis, cancer, and types of mutation.) O The tissue sample responds to treatment with a mitosis-promoting compound. O The tissue sample shows a high level of gene expression relative to a control (noncancerous) sample. O The mRNAs for the targeted tumor suppressor sequence are not being produced. O The mRNAs for cyclins and kinases show unusually high levels of expression.
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