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- 5-6. Choose the best answer from the following questions and provide a one paragraph explanation for your response. 5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate A. Glucose ? B. Oxaloacetate C. acetyl-CoA D. Lactate Explanation for answer in no. 5: 6. In the RBCS of the patient described above, which of the following would be expected A. ADP to ATP ratios would be elevated above normal. B. NADP+ would increase relative to NADPH. ? C. Ribulose 5-phosphate levels would decrease. D. NADH to NAD+ ratios would decrease. E. Methemoglobin levels would increase. Explanation for answer in no. 6:QUESTION: Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? A. Glucose B. Oxaloacetate C. acetyl-CoA D. Lactate CASE STUDY # 2 A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a "blood problem" in her family but doesn't know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made. BIOCHEMICAL MECHANISM: Pyruvate kinase deficiency usually will manifest clinical…Please answer true or false and give explanation. Thank you 4. The coenzyme of monoamine oxidases (MAO) is FAD. 5. Decarboxylation of amino acids is an irreversible process. 6. Does histamine have a vasoconstrictive effect?
- Since in this patient, pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Question is, which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? Explain.Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? a. Glucose b. Oxaloacetate c. acetyl-CoA d. Lactate How does RBC's having no mitochondria do with this?5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? A.Glucose B.Oxaloacetate C.acetyl-CoA D.Lactate Explanation for answer in no. 5: 6.In the RBCS of the patient described above, which of the following would be expected? A.ADP to ATP ratios would be elevated above normal. B.NADP+ would increase relative to NADPH. C.Ribulose 5-phosphate levels would decrease. D.NADH to NAD+ ratios would decrease. E.Methemoglobin levels would increase
- MARIA'S STORY Let's revisit Maria's case. She is a 35-year-old insulin-dependent diabetic who currently takes good care of herself. She did not take good care of herself as a teenager. She is on an insulin pump try to control her blood sugar, but has recently passed out in public several times. a. What condition causes her to pass out? (hyperglycemia or hypoglycemia) b. Why does this condition develop? c. What is the appropriate treatment for the early stag this condition? d. Given that she has been a diabetic before she passes out? Hong, why doesn't Maria realize she is in trouble mano panmbeachschooSWhich LDH isoenzyme is elevated in myocardial infarction? Explain why. What LDH isoenzyme can be use as a liver function test? Explain why.The questions are based on the photo below: 1. How do erythrocytes produce ATP? What is the role of ATP to red-cell morphology and function? 2. How does compromised pyruvate kinase activity lead to anemia?
- Multiple answer question. SELECT ALL THAT APPLY. Which of the following is associated with an increase in hematocrit? Hemophilia O Low WBCS (white blood cells) Anemia Dehydration OIncrease in erythropoietin O Decrease in thrombopoietin • PreviousPLEASE ANSWER BRIEFLY. Thank you. 5. In hairy cell leukemias (HCL), tartrate resistant acid phosphatase is demonstrated. In your opinion, is this the most reliable test to diagnose HCL at present. Explain in not more than 3 sentences. 6. The use of monoclonal antibodies to detect cluster of differentiation (CD) in leukemic cells, mostly immature cells is common in the laboratory. Why do you think this is more valuable than morphological examination of cells in the blood/bone marrow cells.ANSWER BRIEFLY PLEASE. Thank you very much. 9. Case Study: A male patient experienced body malaise, joint pains. He consulted a family medicine physician and was later referred to a hematologist, where bone marrow examination revealed a 10% plasma cells. Myeloma proteins and Bence- Jones protein were demostrated in the blood and urine respectively. a. Is the plasma cell count above, within or below normal/reference value? b. Give the reason why there is higher than normal myeloma proteins in the blood? c. Give the reason why a high level of Bence- Jones protein is detected in urine? d. On the basis of the laboratory results, what do you think is the disease/disorder of the patient?