1. LDA, -78 °C2. PhCH₂Br (1 equiv)☑☑OHSelect to DrawPlease select a drawing or reagent from the question areaIncorrect, 3 attempts remainingUnder basic conditions, the proton alpha to a carbonyl is acidic. Theconjugate base formed from this acid-base reaction is often used as anucleophile in a subsequent substitution reaction. Review the reactionconditions and substrates keeping in mind any relevant stereochemistry orregiochemistry associated with this reaction. Consider counting carbons.Retry

The LDA, -78oC will form a kinetic enolate. Then the enolate attacks on PhCh2Br in order to form a…

Answered: 1. LDA, -78 °C 2. PhCH₂Br (1 equiv) ☑ ☑…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

Section22.SE: Something Extra

Problem 64AP: The key step in a reported laboratory synthesis of sativene, a hydrocarbon isolated from the mold...

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