Essentials of Biology (5th International Edition)
5th Edition
ISBN: 9781259660269
Author: Sylvia S. Mader, Dr., Michael Windelspecht
Publisher: Mcgraw-Hill
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Textbook Question
Chapter 8.4, Problem 1LO
Distinguish between proto—oncogenes and tumor suppressor genes in regard to the development of cancer
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Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.
Explain the difference between proto-oncogene and tumor suppressor mutations in
terms of its potential to cause cancer.
illustrate some of the molecular mechanisms leading from loss-of-function mutations in tumor-suppressor genes to increased predispositions to cancer?
Chapter 8 Solutions
Essentials of Biology (5th International Edition)
Ch. 8.1 - Prob. 1LOCh. 8.1 - Prob. 2LOCh. 8.1 - Prob. 3LOCh. 8.1 - Prob. 1CYPCh. 8.1 - Prob. 2CYPCh. 8.1 - Prob. 3CYPCh. 8.1 - Prob. 1ACh. 8.1 - Prob. 2ACh. 8.2 - Summarize the activities that occur in the cell...Ch. 8.2 - Prob. 2LO
Ch. 8.2 - Prob. 3LOCh. 8.2 - Prob. 4LOCh. 8.2 - Prob. 1CYPCh. 8.2 - Compare and contrast what is occurring during each...Ch. 8.2 - Prob. 3CYPCh. 8.2 - Prob. 4CYPCh. 8.2 - Prob. 3ACh. 8.2 - Prob. 4ACh. 8.2 - Prob. 5ACh. 8.2 - Prob. 6ACh. 8.2 - Label the phases of the cell cycle on the...Ch. 8.2 - Prob. 8ACh. 8.2 - Prob. 9ACh. 8.2 - Prob. 10ACh. 8.2 - Prob. 11ACh. 8.3 - Prob. 1LOCh. 8.3 - Prob. 2LOCh. 8.3 - Prob. 3LOCh. 8.3 - Prob. 1CYPCh. 8.3 - Explain how signals are used for cell cycle...Ch. 8.3 - Prob. 3CYPCh. 8.3 - Prob. 12ACh. 8.3 - Prob. 13ACh. 8.4 - Distinguish between proto—oncogenes and tumor...Ch. 8.4 - 2. Explain the role of telomerase in stem cells...Ch. 8.4 - Prob. 3LOCh. 8.4 - Prob. 4LOCh. 8.4 - Prob. 1CYPCh. 8.4 - Prob. 2CYPCh. 8.4 - Prob. 3CYPCh. 8.4 - Which of the following statements is true? a. The...Ch. 8.4 - 15. Which of the following is not a tumor...Ch. 8.5 - Describe the characteristics of cancer cellsCh. 8.5 - 2. Summarize the types of treatment for cancer
Ch. 8.5 - 3. Describe the factors that reduce the risk of...Ch. 8.5 - 1. List the general characteristics of a cancer...Ch. 8.5 - 2. Summarize the ways that cancer may be...Ch. 8.5 - Explain how lifestyle choices may reduce the risk...Ch. 8.5 - 16. Which of the following is not a feature of...Ch. 8.5 - 17. Which of these is a behavior that could help...Ch. 8 - Prob. 1BYBCh. 8 - Prob. 2BYBCh. 8 - Prob. 3BYBCh. 8 - Prob. S3.2BYBCh. 8 - Section 4.4 What are the roles of the...Ch. 8 - Prob. S4.5BYBCh. 8 - Prob. 1TCCh. 8 - Prob. 2TCCh. 8 - Prob. 3TC
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressedarrow_forwardExplain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause dominantly inherited predispositions to cancer.arrow_forwardHow can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?arrow_forward
- Cancer is driven by alterations in the expression of critical genes, namely tumour suppressors, which play a growth-regulatory role, and proto-oncogenes, which promote the growth and survival of the cell. For both classes of cancer-related gene, suggest a likely mechanism of alteration and sketch the consequence for the gene and protein. Tumour suppressor gene (i.e. TP53, PTEN or APC) Oncogene (i.e. RAS, MYC)arrow_forwardDescribe the difference between a tumor suppressor and an oncogene with respect to the actual causes of cancer.arrow_forwardDescribe the differences between point mutations, chromosomal translocations, and gene amplification in the process of cancer.arrow_forward
- Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, Bcl-2, telomerase, jun, andarrow_forwardDescribe the molecular mechanisms involved in P53’s role as a tumor repressor proteinarrow_forwardExplain how mutations in oncogenes and in tumor suppressorgenes cause cancer.arrow_forward
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