Organic Chemistry (9th Edition)
9th Edition
ISBN: 9780321971371
Author: Leroy G. Wade, Jan W. Simek
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 24.6, Problem 24.13P
Suggest how you would separate the free i-ammo acid from its acylated D enantiomer in Figure24-5.
Figure 24-5
Selective enzymatic deacylation. An acylase enzyme (such as hog kidney acylase or carboxypeptidase) deacylates only the natural L-amino acid.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The second step in the catabolism of most amino acids is the removal of the nitrogen atom from glutamate by oxidative
deamination. In this reaction, glutamate is converted to an a-keto acid.
Modify the structure to show the a-keto acid product.
?-
||
с
I
CH₂
I
H₂N-
&
+ remaining products
enzyme
CH₂
I
CH₂
+ NAD+ + H₂O
CH₂
Incorrect
Enter the chemical formulas for the remaining products.
remaining products: NADH + H+ + NH
Identify the enzyme that catalyzes the reaction.
The enzyme that catalyzes the reaction is glutamate
dehydrogenase.
OH
OH
Other Guide Questions:
1. How is turnover number of an enzyme related to Vmax?
2. How can competitive and non-competitive inhibition be distinguished in terms of Km ?
3. Distinguish between the molecular mechanisms of competitive and non-competitive
inhibition.
4. Why is a Lineweaver-Burk Plot useful in analyzing kinetic data from enzymatic reactions ?
5. What properties of metal ions make them useful cofactors?
6. Why
necessary or advantageous for the body to make zymogens?
7. Briefly describe the role of nucleophilic catalysis in the mechanism of the chymotrypsin
reaction.
8. Please make a derivation of the Michaelis-Menten equation.
Phase II metabolism - glutathione conjugation
Enzymes involved in mercapturic acid formation:
.
●
y-glutamyltranspeptidase
Cysteinylglycinase
N-acetylase
H
Acrolein
Styrene oxide
GSH
GSH
Chapter 24 Solutions
Organic Chemistry (9th Edition)
Ch. 24.2A - Draw three-dimensional representations of the...Ch. 24.2A - Prob. 24.2PCh. 24.2B - The herbicide glyphosate (Roundup) kills plants by...Ch. 24.4 - Draw the structure of the predominant form of a....Ch. 24.4 - Draw the resonance forms of a protonated guanidino...Ch. 24.4 - Although tryptophan contains a heterocyclic amine,...Ch. 24.4 - Prob. 24.7PCh. 24.4 - Prob. 24.8PCh. 24.5A - Show how the following amino acids might be formed...Ch. 24.5B - Prob. 24.10P
Ch. 24.5C - Prob. 24.11PCh. 24.5C - Show how you would use a Strecker synthesis to...Ch. 24.6 - Suggest how you would separate the free i-ammo...Ch. 24.7A - Propose a mechanism for the acid-catalyzed...Ch. 24.7A - Give equations for the formation and...Ch. 24.7B - Prob. 24.16PCh. 24.7C - Prob. 24.17PCh. 24.8B - Draw the complete structures of the following...Ch. 24.9C - Prob. 24.19PCh. 24.9C - Prob. 24.20PCh. 24.9C - Prob. 24.21PCh. 24.9E - Prob. 24.22PCh. 24.9E - Prob. 24.23PCh. 24.10A - Propose a mechanism for the coupling of acetic...Ch. 24.10B - Show how you would synthesize Leu-Gly-Ala-Val-Phe...Ch. 24.10B - Show how solid-phase peptide synthesis would be...Ch. 24 - a. The isoelectric point (pl) of phenylalanine is...Ch. 24 - Prob. 24.28SPCh. 24 - Prob. 24.29SPCh. 24 - Prob. 24.30SPCh. 24 - Prob. 24.31SPCh. 24 - Suggest a method for the synthesis of the...Ch. 24 - Prob. 24.33SPCh. 24 - Write the complete structures for the following...Ch. 24 - The following structure is drawn in an...Ch. 24 - Prob. 24.36SPCh. 24 - Prob. 24.37SPCh. 24 - Show the steps and intermediates in the synthesis...Ch. 24 - Prob. 24.39SPCh. 24 - Lipoic acid is often found near the active sites...Ch. 24 - Prob. 24.41SPCh. 24 - Prob. 24.42SPCh. 24 - Prob. 24.43SPCh. 24 - Complete hydrolysis of an unknown basic...Ch. 24 - Prob. 24.45SPCh. 24 - Prob. 24.46SPCh. 24 - Prob. 24.47SP
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- 1 Drag items from the column on the right to the left to match the pairs Tetrodotoxin Cholera Toxin Pertussis Toxin Beta-blockers BOTOX Blocks aceylcholine release Prevents G-alpha-i from binding GTP. G-alpha-i is unable to inhibit adenylyl cyclase. Results in increased cAMP (mostly in lung cells) Blocks a receptor that activated G-alpha-s, thus, prevents the activation of G-alpha-s. Results in decreased cAMP (mostly in heart cells) Blocks voltage gated sodium channels Prevents G-alpha-s from hydrolyzing GTP. G-alpha- s can't turn off. Results in massive increase of CAMP (mostly in intestinal cells)arrow_forwardIs Non- biologic DMARDs an endogenous substance? If yes, discuss its control of release , biosynthesis and metabolism .Discuss it's Mechanism of action ,the receptor types and physiological function through the specific receptors.arrow_forwardAn enzymatic assay was performed using the enzyme phophofructokinase-1, which catalyses the committed step of the glycolysis pathway. What is the final concentration of the fructose 6-phosphate substrate in a test tube containing the following: 250 µL of 150pM fructose 6-phophate, 100 µL 20 mg.ml-1 phosphofructoskinase-1 and 150 µL 100mM buffer pH 7.5arrow_forward
- Esterase is an enzyme that catalyzes the hydrolysis of esters. It hydrolyzes esters of L-amino acids more rapidly than esters of d-amino acids. How can this enzyme be used to separate a racemic mixture of amino acids?arrow_forwardIf an enzyme-catalyzed reaction has a high rate at low pH and low rate at higher pH, this implies that a group on either the enzyme or the substrate must be for an efficient reaction. leaving group oxidoreductase coenzymes O protonated deprotonated The compound that consists of deoxyribose linked by an N-glycosidic bond to N-9 of guanine is: adenylate deoxyguanosine guanosine nucleotide guanylatearrow_forward22-65 (a) What is the difference in the quaternary structure between fetal hemoglobin and adult hemoglobin? (b) Which can carry more oxygen? (c) What would the oxygen saturation curve of fetal hemoglobin look like compared to that of myoglobin and regular adult hemoglobin?arrow_forward
arrow_back_ios
arrow_forward_ios
Recommended textbooks for you
Introduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage Learning
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Cengage Learning
Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY