Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 23, Problem 1NST

Suppose you initiate a screen for maternal-effect mutations in Drosophila affecting external structures of the embryo and you identify more than 100 mutations that affect these structures. From their screenings, other researchers concluded that there are only about 40 maternal-effect genes. How do you reconcile these different results?

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Summary Introduction

To determine: The method in which one can resolve different results of maternal-effect mutations in Drosophila.

Introduction: A person initiates a screen for maternal-effect mutations in Drosophila which affects the external structures of an embryo. A person identifies more than 100 mutations that affect these structures. On the contrary, other researchers found that there are only about 40 maternal-effect genes.

Explanation of Solution

One can identify several different mutations or multiple alleles in some of the same genes. It may be possible that a person’s screen is more inclusive so that one can identify more subtle alterations than the screen of others. A person’s screen may have included some zygotic effect mutations, which depend on the action of maternal-effect genes.

Conclusion

Thus, different results of maternal-effect mutations in Drosophila can be resolved by identifying several different mutations on the same genes.

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Students have asked these similar questions
Our understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?
If you wanted to analyze the size and abundance of the HOAP protein in an extract from a Drosophila animal that you think may be mutant for the HOAP gene, what method could you use to target your analysis specifically to the HOAP protein in that extract?
For the first experiment ever on Drosophila mutations. Answer the following questions. a. What is the title of the first published paper explained the experiment and what is the name of the Author? b. What is the first mutation discovered in Drosophila? c. Explain the changes in the Drosophila yellow mutant (Y)compared to wild type.
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