Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 12.1, Problem 1CC
How does gene regulation underlie the different morphologies of these cells?
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Describe how Ras and p53 can alter the simplified genetic pathway controlling cell division shown below. For each of the two genes, would uncontrolled cell division result from a loss-of-function or a gain-of-function mutation?
growth factors - receptors - cyclins - cyclin-dependent kinases - cell division
In other words, the master regulator initiates a program of gene expression that narrow the potential fates of the precursor's cells’ descendants to the type of cells that participate in the organ’s function.
Question: Once a master regulator gene is turned on in some cells and not in others, how do cells “remember” that pattern through all the cell division that occur to form a specific organ?
What is the function of a centromere? At what stage of the cellcycle would you expect the centromere to be the most important?
Chapter 12 Solutions
Principles of Biology
Ch. 12.1 - How does gene regulation underlie the different...Ch. 12.1 - Prob. 1TYKCh. 12.1 - The most common point of gene regulation in...Ch. 12.2 - Which genes are under the control of the lac...Ch. 12.2 - Prob. 2CCCh. 12.2 - Prob. 1BCCh. 12.2 - Prob. 1TYKCh. 12.3 - Prob. 1CCCh. 12.3 - Prob. 1TYKCh. 12.3 - Prob. 2TYK
Ch. 12.4 - Prob. 1CCCh. 12.4 - Prob. 1BCCh. 12.4 - A chromatin-remodeling complex may change the...Ch. 12.4 - Prob. 2TYKCh. 12.5 - What is the biological advantage of alternative...Ch. 12.5 - Prob. 2CCCh. 12.5 - Prob. 1TYKCh. 12.5 - Prob. 2TYKCh. 12 - Genes that are expressed at all times at...Ch. 12 - Prob. 2TYCh. 12 - Transcription factors that bind to DNA and...Ch. 12 - Prob. 4TYCh. 12 - Prob. 5TYCh. 12 - Prob. 6TYCh. 12 - Prob. 7TYCh. 12 - Prob. 8TYCh. 12 - Prob. 9TYCh. 12 - Prob. 10TYCh. 12 - What is the difference between inducible and...Ch. 12 - Transcriptional regulation often involves a...Ch. 12 - PRINCIPLES A principle of biology is that the...Ch. 12 - Discuss the advantages and disadvantages of...Ch. 12 - Prob. 2CBQ
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- How do changes in gene expression relate to cell differentiation and specialization? Does every human cell have the same DNA, RNA or proteins?arrow_forwardDo cells which lack normal cell cycle control (cancerous cells) exhibit karyotypes that look physically different than cells with normal cell cycle control?arrow_forwardWhat is the fundamental molecular difference that distinguishes a stem cell?arrow_forward
- How does gene expression influence the behavior of cells that contain the same genome (genetic information)? In other words, why do cells that belong to the same multicellular organism have a different structure and function?arrow_forwardHow does gene affects migrating cells?arrow_forwardI am confused about how stem cell transplants works. If you put a semi differentiated tadpole nucleus in a denucleated egg cell, it’ll develop into a fully formed tadpole, but if you put a fully differentiated tadpole nucleus, it won’t (because the genes have already been expressed in a way where the cytoplasmic determinants cannot operate to the fullest). Then how come in stem cell transplants, you use adult nucleuses that are already developed and transplant them into the denucleated egg cells?arrow_forward
- A cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .arrow_forwardHow are molecules inherited asymmetrically during cell division?arrow_forwardBy what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?arrow_forward
- What is the nuclear division that apportions chromosomes in equal fashion to two daughter cells, is the cellular mechanism that preserves genetic information through all these generations of cells?arrow_forwardHow do normal cells protect themselves from accumulating mutations in genes that could lead to cancer? How do cancer cells differ from normal cells in these processes?arrow_forwardHow do cells control gene expression? How do cell "switch" genes on/off? Draw a flow chart to match?arrow_forward
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Cell Division - Mitosis and Meiosis - GCSE Biology (9-1); Author: Mr Exham Biology;https://www.youtube.com/watch?v=w7vp_uRA8kw;License: Standard YouTube License, CC-BY