Which of the following statements are correct about inflammation and cancer (select all that apply)? A. Inflammatory cells are often detected in tumor samples B. The inflammatory cytokine TNF has been shown to have direct transforming properties C. Cancer often arises at sites of chronic inflammation D. Use of NSAIDs has been associated with increased mortality from colorectal cancer E. Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosis

Which of the following statements are correct about inflammation and cancer (select all that apply)? A. Inflammatory cells are often detected in tumor samples B. The inflammatory cytokine TNF has been shown to have direct transforming properties C. Cancer often arises at sites of chronic inflammation D. Use of NSAIDs has been associated with increased mortality from colorectal cancer E. Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosis

Ebk:Nutrition & Diet Therapy

10th Edition

ISBN:9780357391747

Author:DEBRUYNE

Publisher:DEBRUYNE

Chapter24: Energy- And Protein- Modified Diets For Metabolic And Respiratory Stress

Section: Chapter Questions

Problem 3SC

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Why is anti-angiogenic therapy an attractive attack method against cancer? Select one: o a. Endothelial cells are relatively stable cells a. Endothelial cells are relatively stable cells o b. Killing one endothelial cell effectively kills hundreds of cancer cells o c. Antiangiogenic therapy can be combined with existing cancer therapies o d. all of the above
Cancer cells have a complex interaction with the cells of the immune system that are present in the stroma. The immune cells have the potential to destroy the tumor if it is recognized as aberrant tissue. Which one of the following statements correctly describes an interaction between cancer cells and the immune cells of the stroma? A. Tumors stimulate formation of new blood vessels—angiogenesis—promoting tumor survival. B. The tumor establishes an immunosuppressive environment by blocking white-cell activation. C. Tumors invoke an inflammatory reaction that blocks entry of immune cells into the stroma. D. Immune cells block tumor growth by providing signals that inhibit cancer cell proliferation.
Which of the following statements are correct about tumor cell masses (select all that apply)? A. Stromal cells of tumor masses are generally just contaminants and play no role in tumor progression B. Most stromal cells are of mesenchymal origin C. Fibroblasts, macrophages and lymphocytes are commonly found in the stroma of tumor masses D. In Hodgkin's Lymphoma, the majority of cells in the tumor mass are neoplastic E. In carcinomas, neoplastic and stromal cells are present at similar numbers
Which of the following drugs is a clinically-used monoclonal antibody for the treatment of breast cancer? O a. Doxycycline O b. Chloroquine O c. Herceptin O d. Protium
Which of the following statements are correct about tumors and metastasis (select all that apply)? A. The majority of cancer deaths are due to primary tumor B. Loss of basement membrane by tumor mass is strong predictor of metastasis potential C. The tissue stroma contributes to whether a tumor cell will metastasize D. The majority of life threatening tumors occur in epithelial tissues E. The tendency of a primary tumor to metastasize is similar across different tissue types
Which of the following statements are correct about cancer drug resistance (select all that apply)? A. It is inevitable that a tumor will eventually become resistant to a given cancer drug B. Solid tumors often develop drugs resistance through upregulating expression of drug transporters. C. If the probability of develop resistance to drug A is 1/10 and for Drug B is also 1/10, then the probility of developing resistance to Drug A and B combination therapy is 1/20. D. Effective multidrug protocols use 3 drugs that all target the same mechanisms of killing cancer cell E. Drug resistance ofter develops when p53 is inactivated
Which of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply: a. Increasing tumor's access to oxygen and nutrients b. Increasing tumor's ability for growth, invasion, and metastasis c. Increasing expression of proto-oncogenes for cancer cells d. Increasing expression of tumor-suppressor genes for cancer cells
The therapeutic index of an anti-cancer drug is reflective of which of the following(select all that apply)? A. Method by which drug is delivered B. The dosage at which side effects are minimal C. The number of patients receiving drug D. Selectivity over cancer cells vs normal cells E. The molecular target of the drug
Our government has finite funds to devote to cancer research.Discuss which of the following areas of research you think shouldreceive the most funding.A. Identifying and characterizing oncogenes and tumorsuppressorgenesB. Identifying agents in our environment that cause cancerC. Identifying viruses that cause cancer D. Devising methods aimed at killing cancer cells in the bodyE. Informing the public of the risks involved in exposure tocarcinogensIn the long run, in which of these areas would you expect successfulresearch to be the most effective in decreasing human mortalitydue to cancer?
Explain why each choice (a-d) is correct or incorrect. All but one of the following occurs during the inflammatory response. Select the example below that does NOT describe the process of inflammation. a. Inflammation increases capillary permeability. b. Chemotaxis draws leucocytes to the site of injury. c. Vasoconstriction prevents excessive blood loss due to injury. d. Release of prostaglandins results in pain.

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	A.	Inflammatory cells are often detected in tumor samples
	B.	The inflammatory cytokine TNF has been shown to have direct transforming properties
	C.	Cancer often arises at sites of chronic inflammation
	D.	Use of NSAIDs has been associated with increased mortality from colorectal cancer
	E.	Levels of macrophage infiltration in tumors have been negatively correlated with patient prognosis