Which of the following is not a CYP450 catalyzed oxidation/reduction reaction? O A. deamination OB. hydroxylation c.epoxidation OD. N-demethylation O E. alcohol oxidation
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- Define the following terms:a. cytochrome P450b. mixed-function oxidasec. flavin-containing monooxygenased. detoxicatione. detoxificationDefine the following terms: a. sdLDL b. oxLDL c. cytochrome P450 d. atheroma e. abetalipoproteinemiaCytochrome P450 (CYP450) monoxygenase is the enzyme involved in Phase I metabolism. 450 refers to: * It can metabolize 450 drugs when in the reduced form and complexed to carbon monoxide It can produce 450 drugs when in the oxidized form and complexed to carbon dioxide It can emit light at 450 nm when in the oxidized form and complexed to carbon monoxide It can absorb light at 450 nm when in the reduced form and complexed to carbon dioxide It can absorb light at 450 nm when in the reduced form and complexed to carbon monoxide
- FAD is reduced in which of the following reactions/transformations in the Krebs cycle? a. Succiny| CoA to succinate b. Isocitrate to oxaloacetate c. Fumarate to malate d. Succinate to fumarateWhich statement on the biosynthesis of cannabinoids is NOT TRUE? Select one: O a. Geranyl pyrophosphate is formed as a precursor via the deoxyxylulose pathway in cannabis O b. Divarinic acid is the precursor for the production of propyl cannabinoid acids. O C. When prenyl-transferase enzyme uses olivetolic acid as substrate cannabigerivarinic acid (CBGVA) is formed. O d. THCA-synthase, CBDA-synthase, and CBC- synthase enzymes can use both CBGA and GBGVA as substrate.Which of the following is incorrect about the chymotrypsin mechanism? a. When His removes a proton from Ser, it is acting as an acid b. Asp does not act as an acid c. Asp, through a H-bond, holds His in the proper orientation Od. After being deprotonated, Ser acts as a nucleophile
- Which of the following statements concerning uncompetitive inhibitors is NOT true? a. They decrease the Km b. c. Od. O e. They bind to both ES and Enzyme They decrease the Vmax They bind to ES only No product is formed after their bindingDuring Cytochrome P450-catalyzed monooxygenation... ... iron is being both reduced and oxidized, while other atoms never change their oxidation state iron is being reduced, while hydrogen is being oxidized O O O ... oxygen is being reduced, while hydrogen is being oxidized carbon is being reduced, while hydrogen is being oxidized carbon is being oxidized, while oxygen is being reducedWhich of the following is incorrect about chymotrypsin? It uses acid-base catalysis b. It has three essential amino acid residues (called the catalytic triad) at the active site It does not use metal catalysis d. It does not use covalent catalysis a. O c.
- In which of the given steps of TCA cycle one C is lost from substrate in the form of CO2 as well as a molecule of NAD+ is reduced? a.Oxalosuccinic acid to a-ketoglutaric acid b.Isocitrate to oxalosuccinic acid c.Malic acid to oxaloacetic acid d.a-ketoglutaric acid to succinyl CoAWhich of the following pathways requires molecular oxygen (O2)? a. aerobic respiration b. lactate formation c. alcoholic fermentation d. photosynthesisHelp me please