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What types of GPCRs act in nociceptors to induce excitatory signaling?
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- Please ASAP. Thanku. Please provide a brief explaination. Qs 2 What will increase the length constant of axons?Please ASAP. Thanku. What is the effect of increasing the activity of HCN (Ih) channels on action potential firing rate?Please asap. thanku If you gave someone a non-selective blocker of P2X channels,what functions would be impaired?
- Draw a cell. Draw a receptor that binds to a signaling molecule on the outside of the cell and a receptor that binds to a signaling molecule on the inside of the cell. What property does a signaling molecule that crosses the cell membrane (plasma membrane) need?Would like a better explanation on Foxp3. Typed what I know for the first questoin In the discussion section the authors wrote “In a previous study, Dombrowski et al. [44], has reported that Treg cells are able to promote myelination and remyelination and its transcriptional factor, Foxp3, is a good indicator of Tregs activity [21, 45].” Where in the cell does Foxp3 act? The FOXP3 protein is found in an immune system gland called the thymus, where regulatory T cells are produced. Foxp3 is a master regulator of transcription in a specific T-cell type, CD4 (+) regulatory T cells (Treg). Foxp3 is a good indicator of Tregs activity. By what word or words in the quote of question 10 do you know that your answer to question 10 is correct?Please help me with this question. More than one answer may be correct. G-proteins ______. Options: A) bind GTP or GDP B) are heterotrimers C) will dissociate into α and βγ subunits when activated D) will leave the cell and carry a signal to other cells E) are part of a second messenger system
- . Compare and contrast signalling through a ligand-gated ion channel and a G-protein coupled receptor, using specific examples.Please ASAP. Thankyou. What are the two immune cells that are temporally regulated in a peripheral injury response by the CNS? a.Oligodendrocytes and Schwann cells b.Microglia and astrocytes c.Astrocytes and oligodendrocytes d.Schwann cells and astrocytesPlease help me with this question. More than one answer may be correct. Gap Junctions ______. Options: A) can be closed by increase [cAMP] B) are made of a protein complex called connexon C) are made of a protein complex called hemichannel D) can be closed by increase [Ca++] E) can be closed by decreased pH
- Vision. Recall that muscarinic ACh receptors are located on smooth muscle tissue. The iris is composed of smooth muscle and is responsible for dilation and constriction of the pupil. Tropicamide is a medication applied to the eye during an eye exam. If Tropicamide is an antagonist to the muscarinic receptors, what effect will this have on the eye? Why do you have difficulty seeing well while you wait for the effects of this medicine to wear off?三。 Normal No Spacing Heading 1 Heading 2 Title Subtitle a) Create a diagram which illustrates the typical signalling mechanism of action of each of the four common classes of receptor (e.g. kinase-linked receptors etc.) and possible routes of communication (autocrine etc.). Your diagram should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. b) For each of the examples describe the mechanism of action in the form below..GPCR: What would the following mutation mean for the status of the signaling pathway, and the generation of cAMP from ATP? 1) G-protein coupled receptor (GPCR) Loss of Function, in combination with Gain of function of PKA catalytic subunitsa) Pathway ON (final output achieved)b) Pathway OFF (no final output)c) cAMP generatedd) cAMP not generated 2) G-protein coupled receptor (GPCR) Gain of Function, in combination with Loss of function of PKA catalytic subunitsa) Pathway ON (final output achieved)b) Pathway OFF (no final output)c) cAMP generatedd) cAMP not generated