The following image shows the 'beads-on-a-string' model of DNA and the effects of histonemodification on chromatin structure.What effect does histone acetylation have on Gene 1?Gene 1De-acetylationAcetylationAcAcGene 1AcAc AcO Acetylation increases expression of Gene 1O Acetylation decreases expression of Gene 1O Acetylation causes a mutation in Gene 1O There is no way to tell from this figure

Name: The following image shows the 'beads-on-a-string' model of DNA and th
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Description: The following image shows the 'beads-on-a-string' model of DNA and the effects of histonemodification on chromatin structure.What effect does histone acetylation have on Gene 1?Gene 1De-acetylationAcetylationAcAcGene 1AcAc AcO Acetylation increases

Histone acetylation is an epigenetic modification of transcription . Histone acetylation is the…

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Science

Biology

What effect does histone acetylation have on Gene 1?

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter16: Gene Expression

Section: Chapter Questions

Problem 39CTQ: New drugs are being developed that decrease DNA methylation and prevent the removal of acetyl groups...

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Give at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosome
In studies on chromatin it has been reported that DNA that is being actively transcribed is more sensitive to digestion by DNase I. Which of the following events is known to make DNA more sensitive to digestion by DNase I? Formation of heterochromatin DNA methylation All of the provided answers are correct. Acetylation of histone O Deacetylation of histone
You discover a histone variant that has more positive charge than conventional histone proteins. What effect do you predict this histone variant would have when it is inserted into chromatin? A decrease in the strength of histone-DNA interaction, making chromatin less condensed and increasing gene expression An increase in the strength of histone-DNA interaction, making chromatin less condensed and decreasing gene expression An increase in the strength of histone-DNA interaction, making chromatin more condensed and decreasing gene expression O A decrease in the strength of histone-DNA interaction, making chromatin less condensed and decreasing gene expression
Why do chromatin remodeling factors exist? Remodeling factors are not essential but help regulate gene expression. O Nucleosomes are intrinsically immobile on a biological timescale at physiological conditions. Remodeling factors are essential regulators of gene expression through covalent modification of histone tails.
Which of the following is likely to be transcriptionally expressed? euchromatin and DNA with methyl groups euchromatin DNA with methyl groups DNA with acetylated histones euchromatin and DNA with acetylated histones
Genes are not always active in cells. The cell has evolved to edit its chromatin state in accord with the energy needs of the cell and organism. What are these two kinds of chromatin called and how does chromatin modeling work in cells? Name four of the known families of chromatin remodeling complexes enzyme complexes that act directly on DNA to alter nucleosome composition in transcribed regions.
Typically, increased acetylation and decreased methylation of histone N-terminal tails in nucleosomes leads to removal of the protein components of the chromatin from the DNA relaxed packaging of the chromatin and increased transcription increased amounts of euchromatin relative to heterochromatin activation of topoisomerase tighter packaging of the chromatin and reduced transcription
Describe how methylation and acetylation of the histones changes gene expression in eukaryotes. What groups are added? How do these processes physically affect chromatin structure? Silencing or Enhancing expression?
Base on your knowledge of DNA, chromosomes and epigenetics and upon examining the picture below, name two epigenetic factors and at least one non-epigenetic factor present on this picture. [HINT: which of the factors shown on the picture do you expect to change based on the interactions with an environment and which you expect unchanged?] Methyl Group DNA Chromatin Epigenetic Factor Histone Histone Tails Chromosome
Compared to heterochromatin, euchromatin is comprised of densely packed nucleosomes and with higher transcription activity comprised of densely packed nucleosomes and with lower transcription activity O comprised of loosely packed nucleosomes and with lower transcription activity Ocomprised of loosely packed nucleosomes and with higher transcription activity
What effect would inhibitors of histone deacetylases have upon transcription? Group of answer choices They would increase transcription by making the chromatin more compact They would increase transcription by making the chromatin less compact They would decrease transcription by making the chromatin more compact They would decrease transcription by making the chromatin less compact For this question, we will consider a eukaryotic mRNA that has four exons (E1, E2, E3, E4) and three introns (I1, I2, I3). What could occur if a protein were to bind over the 3' splice site of intron 2 (I2)? Group of answer choices The processed mRNA would consist of: E1+E2+E3+E4 The processed mRNA would consist only of: E1+E3 The processed mRNA would consist only of: E3+E4 The processed mRNA would consist of: E1+E2+E4
You have discovered a new species of plant. You isolate chromatin from the plant and examines it with the electron microscope and see characteristic beads on a string structure. After addition of a small amount of nuclease, which cleaves the string into individual beads that each contain 280 bp of DNA. With more digestion a 120-bp fragment of DNA remains attached to a core of histone protein. Analysis of the histone core reveals histones in the following proportions: H2A 33.3% H2B 33.3% H3 0% [no histone H3 found] H4 33.3% Based on these observations, what conclusions can you make about the probable structure of the nucleosome in the chromatin of this plant? Be specific in describing the nature of the nucleosome: which histones form the core (), how many of each are present () and size in bp of core-DNA that envelopes it ().