Troponin C has been mutated such that it cannot bind to calcium. Describe the effect of this mutation on sarcomere shortening in skeletal muscle. A complete answer will describe the normal function of troponin C, the normal process of sarcomere shortening, and will describe the overall effect of the mutation on sarcomere shortening based on troponin C's function and its role in the overall process of sarcomere shortening.
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- Impairment of intracellular calcium homeostasis in muscle fibers lead to chronic, severe muscle dysfunction. Impaired Calcium ATPase activity can lead to abnormal, persistent elevation of intracellular calcium concentrations. Explain how persistently high intracellular calcium concentration would affect cross-bridge formation, and muscle contractions, and muscle tension? (Mention the effects on the steps involved cross bridge formation, and muscle contraction/relaxation cycle, and overall muscle tension).Image A Image B Z M F. The images above represent the contracting unit of a muscle fiber. Using the images shown, answer the following questions. Be sure that you label your answers a, b and c. a. What is a contracting unit of a myofibril called? b. Which image represents a myofibril that is fully contracted? c. Explain how you derived your answer to part b. Be sure to use the words for the myofilaments that are involved in muscle contraction in your answer.one of the early symptoms of calcium deficiency is muscle cramps. explain why by outlining through a concise pathway of muscle contractions underlining the first step that is affected by calcium deficiency.
- Discuss how calcium is a signaling molecule that causes the contraction of the sarcomere. This discussion should include the molecular mechanisms of tricep contraction. A ▾ B I √ C I U Ꭶ C X₂ C !!! x² Il = = E lılıPluripotent stem cells undergo a number of changes as they progress through developmental stages to become the terminally differentiated cell type known as a skeletal muscle myofiber. a) Describe the stages and key anatomic and functional changes that occur during differentiation of myofibers. b) Despite the fact that myofibers are terminally differentiated, muscle can regenerate itself following a trauma or injury. Describe how this can occur.Certain multi-headed myosins bind cooperatively to actin filaments. The binding interaction is mainly electrostatic in nature, so the presence of additional salt (ions) in solution can interfere with binding; ions will tend to associate with charged residues on the two proteins, blocking electrostatic attractions that would otherwise take place. Briefly describe the expected shape of the binding curve for one of these myosins, and what will happen to the shape when the salt concentration increases.
- Discuss how calcium is a signaling molecule that causes the contraction of the sarcomere. This discussion should include the molecular mechanisms of tricep contraction.For the following five events, which is the correct sequence that describes the excitation and contraction of a skeletal muscle fiber? 1. Tropomyosin shifts, exposing the myosin-binding sites on actin. 2. Calcium is released from the sarcoplasmic reticulum and binds to the troponin complex. 3. An action potential is propagated down the transverse tubules. 4. Cycles of myosin cross-bridge formation and breakdown cause the thin filaments to slide toward the center of the sarcomere. 5. An action potential in a motor neuron causes the axon to release acetylcholine, which triggers an action potential in a muscle fiber. 1 → 2 → 3 → 4 → 5 3 → 2 → 4 → 1 → 5 2 → 1 → 3 → 5 → 4 5 → 3 → 2 → 1 → 4 4 → 3 → 1 → 2 → 5What is a sarcomere? Illustrate how Z disks, actinmyofilaments, myosin filaments, the M line, and titin form asarcomere. Describe how this arrangement produces theA band, the I band, and the H zone. Label these areas onyour illustration.
- A typical relaxed sarcomere is about 2.3 um in length and contracts to about 2 um in length. Within the sarcomere, the thin filaments are about 1 um long and the thick filaments are about 1.5 um long. (a) Describe the overlap of thick and thin filaments in the relaxed and con- tracted sarcomere. (b) An individual "step" by a myosin head in one cycle pulls the thin fila- ment about 15 nm. How many steps must each actin fiber make in one contraction?A) tetany is rapid spasm in the muscle. B) Tetany is usually caused by an increase in the blood calcium levels. Write whether statement (B) is correct w.r.t statement (A) ?1) Paula is a scientist who is developing a drug called Fremtol that will be used to treat muscle spasms. This drug acts on specific skeletal muscles to (1) block the release of Ca2+ ions from the sarcoplasmic reticulum, (2) inhibit the pivoting ability of the myosin heads of the thick filaments, and (3) block the production of ATP by the mitochondria in skeletal muscles. By using this drug, contraction of certain skeletal muscle fibers is reduced, which keeps those muscles from producing spasms. In the above scenario, Fremtol’s effect of blocking the pivoting ability of the myosin heads of the thick filaments would have which of the following consequences? a. decreased release of acetylcholine at the neuromuscular junction b. inhibition of the power stroke c. reduced production of myoglobin d. All of the above e. None of the above 2) Paula is a scientist who is developing a drug called Fremtol that will be used to treat muscle spasms. This drug acts on specific skeletal muscles to…