This image shows the alignment of the promoter from the same gene (gene H) across multiple mammalian and bird species.  Predict how the following two mutations will affect the amount of gene expression from gene H in M. musculus (the mouse, underlined with a blue line).  A) The T marked by the first arrow is mutated to a G. This will ______expression of gene H.  Increase decrease Abolish  Not change B) The G marked by the second arrow is mutated to a A. This will _____expression of gene H.  Increase decrease Abolish  Not change

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter16: The Neurological Exam
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This image shows the alignment of the promoter from the same gene (gene H) across multiple mammalian and bird species. 

Predict how the following two mutations will affect the amount of gene expression from gene H in M. musculus (the mouse, underlined with a blue line). 

A) The T marked by the first arrow is mutated to a G. This will ______expression of gene H. 

Increase

decrease

Abolish 

Not change

B) The G marked by the second arrow is mutated to a A. This will _____expression of gene H. 

Increase

decrease

Abolish 

Not change

B
Mammals
Birds
H. sapiens
E. caballus
B. taurus
O. aries
C. hircus
S. scrofa
O. cuniculus
M. musculus
G. gallus
C. chinensis
CAAT box
AI
TATA box
TATA box
AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCAAG--TGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCATAGACCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATCAAAG
AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCCTCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATACAGG
AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGCA-----TATATAAG
AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTCGCAGTATAAAAGCCCCCTTGGCA- ---TATAAAA
-TATATAAG
A. platyrhynchos AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA-
A. anser
AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA-----TATATAAG
Transcribed Image Text:B Mammals Birds H. sapiens E. caballus B. taurus O. aries C. hircus S. scrofa O. cuniculus M. musculus G. gallus C. chinensis CAAT box AI TATA box TATA box AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCAAG--TGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCATAGACCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATCAAAG AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCCTCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATACAGG AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGCA-----TATATAAG AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTCGCAGTATAAAAGCCCCCTTGGCA- ---TATAAAA -TATATAAG A. platyrhynchos AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA- A. anser AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA-----TATATAAG
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