There is a proposal that pyrazole could protect against the damaging effects of alcohol on the liver that result from prolonged decrease in the ratio of [NAD+]/[NADH] caused by the oxidation of alcohol. ( NAD+ is required for several key dehydrogenation steps in the pathway of glucose synthase. NADH promotes the accumulation of fat in the liver cells) Assuming that pyrazole is not toxic and that it is transported to the liver, evaluate its potential as an antidote to liver damage in treating chronic alcoholism. Would it be a reasonable therapeutical candidate? Explain. Please explain and please don't copy bartleyby answer.
There is a proposal that pyrazole could protect against the damaging effects of alcohol on the liver that result from prolonged decrease in the ratio of [NAD+]/[NADH] caused by the oxidation of alcohol. ( NAD+ is required for several key dehydrogenation steps in the pathway of glucose synthase. NADH promotes the accumulation of fat in the liver cells) Assuming that pyrazole is not toxic and that it is transported to the liver, evaluate its potential as an antidote to liver damage in treating chronic alcoholism. Would it be a reasonable therapeutical candidate? Explain. Please explain and please don't copy bartleyby answer.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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There is a proposal that pyrazole could protect against the damaging effects of alcohol on the liver that result
from prolonged decrease in the ratio of [NAD+]/[NADH] caused by the oxidation of alcohol. ( NAD+ is
required for several key dehydrogenation steps in the pathway of glucose synthase. NADH promotes the
accumulation of fat in the liver cells) Assuming that pyrazole is not toxic and that it is transported to the liver,
evaluate its potential as an antidote to liver damage in treating chronic alcoholism. Would it be a reasonable
therapeutical candidate? Explain.
Please explain and please don't copy bartleyby answer.
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