An RCT was designed to test the effectiveness of naltrexone, an opiate receptor antagonist, as a treatment for alcohol dependence.  Subjects with chronic severe alcohol dependence were randomly assigned to either 3 months of naltrexone treatment or 3 months of placebo treatment.  The number of drinks per drinking day was compared between the two groups.  Let μ1= population mean number of drinks per drinking day for those on Naltrexone and μ2= population mean number of drinks per drinking day for those on placebo.  The data from the study are summarized in the table below.   Naltrexone (n1 = 196) Placebo (n2=195) Mean Number of drinks per drinking day Xbar1=10.5 Xbar2=9.3 Standard Deviation of Number of drinks per drinking day S1 = 80 S2 = 7.0 The investigators want to test whether there is a significant difference between the two groups using a 5% significance level. 1. What is the most appropriate test to address the investigators’ research question? a. Pearson’s Chi-Squared Test b. ANOVA c. Two-sample t-test assuming unequal variances d. Paired t-test e. Two-sample t-test assuming equal variances   2. Write the correct null and alternative hypothesis for the appropriate test     3. Using one of the probability tables provided to you, compute the p-value corresponding to the test statistic value from part (c) as accurately as possible.  Which range does the p-value fall in? What is your conclusion for the hypothesis test based on this p-value?   a. 0.005 < p < 0.01 b. 0.01 < p < 0.02 c. 0.10 < p < 0.20 d. 0.02 < p < 0.05 e. 0.05 < p < 0.10

Glencoe Algebra 1, Student Edition, 9780079039897, 0079039898, 2018
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Chapter4: Equations Of Linear Functions
Section4.5: Correlation And Causation
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An RCT was designed to test the effectiveness of naltrexone, an opiate receptor antagonist, as a treatment for alcohol dependence.  Subjects with chronic severe alcohol dependence were randomly assigned to either 3 months of naltrexone treatment or 3 months of placebo treatment.  The number of drinks per drinking day was compared between the two groups.  Let μ1= population mean number of drinks per drinking day for those on Naltrexone and μ2= population mean number of drinks per drinking day for those on placebo.  The data from the study are summarized in the table below.

  Naltrexone
(n1 = 196)

Placebo

(n2=195)

Mean Number of drinks per
drinking day
Xbar1=10.5 Xbar2=9.3
Standard Deviation of Number
of drinks per drinking day
S1
= 80
S2
= 7.0

The investigators want to test whether there is a significant difference between the two groups using a 5% significance level.

1. What is the most appropriate test to address the investigators’ research question?

a. Pearson’s Chi-Squared Test
b. ANOVA
c. Two-sample t-test assuming unequal variances
d. Paired t-test
e. Two-sample t-test assuming equal variances
 
2. Write the correct null and alternative hypothesis for the appropriate test
 
 
3. Using one of the probability tables provided to you, compute the p-value corresponding to the test statistic value from part (c) as accurately as possible.  Which range does the p-value fall in? What is your conclusion for the hypothesis test based on this p-value?
 
a. 0.005 < p < 0.01
b. 0.01 < p < 0.02
c. 0.10 < p < 0.20
d. 0.02 < p < 0.05
e. 0.05 < p < 0.10
 
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Follow-up Question
 the the 95% confidence interval for the true difference in mean number of drinks per drinking day between those taking Naltrexone and those taking placebo would:

a. Include the estimated difference in the means.
b. Include 0 and the estimated difference in the means.
c. Include 0.
d. Not include 0.
e. Not include 0 and include the estimated difference in the means.
Solution
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Follow-up Question
The 95% confidence interval for the true difference in mean number of drinks per drinking day between those taking Naltrexone and those taking placebo would:

Include the estimated difference in the means.
Include 0 and the estimated difference in the means.
Include 0.
Not include 0.
Not include 0 and include the estimated difference in the means.
Solution
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