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- Using the pedigree, assume that the disease is caused by an autosomal dominant allele, R. Give the genotype of the following individuals: (a) III-4 (the girl at lower right) (b) II-3 (the girl’s mother) (c) II-4 (the girl’s father)The pedigree shows the inheritance of a disease or trait in three generations of a family (Attached image below) I. It is possible to rule out autosomal dominant inheritance II. It is possible to rule out autosomal recessive inheritance a) I = TRUE, II = TRUE b) I = TRUE, II = false c) I = false, II = TRUE d) I = false, II = false➡ Listen DOI The pedigree shown is A) Autosomal Dominant B) Autosomal Recessive C) Sex linked recessive D) Sex linked dominant Goth
- Pedigree attached shows an autosomal recessive genetic disease. G is the normal allele and g is the disease-causing allele. Individual 1’s father is heterozygous (*) and his mother is homozygous dominant. Other individuals in the pedigree may be carriers, but are not marked. The question mark (?) indicates that you do not yet know anything about this individual’s phenotype with regard to the disease. part a) What is the probability that individuals 1 and 2 will have a child (5) who is a boy with the disease (the child is unborn and the sex is not yet known)? a)1/8 b)1/4 c)0 d)1/16 part b) What is the probability that the daughter (6) that individual 3 and 4 just had will have the disease? a)1/8 b)1/6 c)1/4 d)1/12The pedigree shows a family in which several members have suffered from one and the same disease (look at the picture to be able to answer) a) Is it a dominant or recessive allele that causes the disease? Motivate your answer. b) Is allele autosomal or sex-linked? Motivate your answer. c) What is the probability that III-3 and III-4 will have a healthy child? Motivate your answer.The pedigree below shows a family with a history of an autosomal recessive genetic disease with one individual's genotype indicated (G denotes the normal allele and g denotes the disease-causing allele). * O 0 O 1/8 1/4 O 1/16 Individual 1's father is known to be heterozygous (*) and his mother is known to be homozygous dominant. Other individuals in the pedigree may be carriers, but are not marked. The question mark (?) indicates that you do not yet know anything about this individual's phenotype with regard to the disease. Part 1 What is the probability that individuals 1 and 2 will have a child (5) who is a male with the disease (the child is unborn and the sex is not yet known)? O 1/4 1 O 1/6 5 1/8 2 01/12 gg 3 Part 2 What is the probability that the daughter (female)(6) that individual 3 and 4 just had will have the disease? 6
- Refer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd ddThis pedigree consist of cystic fibrosis that is an inherited disease caused by f a recessive allele. Find the genotypes of X and M? Given: O normal female □ normal male ◍ cystic fibrosis female ▨ cystic fibrosis male A) M= Ff X=Ff B) M=Ff X=ff C) M=ff X=ff D) M=ff X=FFBlank 1) s the trait in this pedigree dominant or recessive? Blank 2) What is the genotype of the individual indicated by the red arrow? (Use the letter A Blank1 recessive Blank2 A
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).In this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected || IV V 5600 orize 077808 15 10 9 10 CHO વ Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk.…The individuals with a certain disease are shown in this pedigree. The disease is caused by an autosomal recessive allele, q. Give the genotype of the following individuals: (a) III-1 (the girl at lower left corner) (b) II-1 (the girl’s mother) (c) II-2 (the girl’s father)
