The following intermediate was needed for the synthesis of tamoxifen, a widely used antiestrogen drug for treating estrogen-dependent cancers such as breast and ovarian cancer. Needed for the (A) synthesis of tamoxifen Propose a synthesis for this intermediate from compound A.
Q: Adding acetophenone slowly to a cold solution of LDA produces the enolate of acetophenone; but…
A: SOLUTION: Step 1: The organic reaction in which a chemical compound containing a carbonyl group acts…
Q: Describe how the following compounds could be prepared from cyclohexanone using an enamine…
A: Only one set of ketone and alkyl halide could be used for the synthesis of given compounds. The set…
Q: (c) HO.
A: The synthesis of the target molecule starting from the given starting material is proposed below.
Q: e a plausible arrow pushing mechanism for the following transformation. Hint: hydrolysis of acetal…
A: Acetals are the functional groups that are also used as the protecting groups for certain functional…
Q: (d)
A: We can proceed this transformation on two simple steps. Let us try to draw these steps.
Q: Br CH,CO,H +Br, CH,CO,H CH3 `CH,CO,H CH3 A bromolactone
A:
Q: hat steps are needed to convert benzene into p-isobutylacetophenone, a synthetic intermediate used…
A:
Q: What is the major product formed by an intramolecular Friedel–Crafts acylation of the following…
A:
Q: Show how to prepare the following compound by the synthesis of malonic acid
A: Esterification is a process of combining organic acid with an alcohol to form ester and water.…
Q: What is the mechanism for the esterification of vanillin to vanillyl acetate, under basic…
A: In this question, we need to draw the reaction mechanism for this two steps reaction and balanced…
Q: Compound A was reacted with ozone (oxidative cleavage). The product formed was 5-oxohexanal…
A:
Q: Give the structures of the two substrates that are required to synthesize the following drug against…
A: The molecular structure of the required drug is provided. It can be synthesized by Knorr pyrrole…
Q: What acid chloride would be needed to prepare each of the following ketones from benzene using a…
A: Friedel–Crafts acylation:- Those reactions in which acyl halide reacts with benzene in the presence…
Q: please help with this question. thank you. The following sequence, beginning with a cyclic…
A: (1) Ring opening of A (Hemiocetal):
Q: The Stork reaction is a condensation reaction between an enamine donor and an a,ß-unsaturated…
A:
Q: H. (a) (b)
A: Aldol condensation reaction - two moles of aldehyde (or ketone) in presence of strong base react…
Q: This question has multiple parts. Work all the parts to get the most points. The Stork reaction is a…
A:
Q: Depict a competent mechanism for the formation of DEET using m-toluic acid and oxalyl chloride, with…
A: Synthesis of DEET using m-toluic acid, oxalyl chloride and diethylamine, whose mechanism is to be…
Q: The Stork reaction is a condensation reaction between an enamine donor and an a,ß-unsaturated…
A:
Q: n synthesis of benzoic acid with Grignard reagent, benzene is often detected as an impurity. How is…
A: Grignard Reagent Are very Powerful base which Takes Place H+ From solution and get converted…
Q: Provide a synthesis for the following transformation. Ethyl acetoacetic ester and any other…
A:
Q: When there is Treatment of Compound E with sodium amide and then methyl iodide it does not produce…
A: NaNH2 or NH2- is a strong base that reacts with very weak acid to form NH3(aq)
Q: Devise a synthesis of valproic acid [(CH3CH2CH2)2CHCO2H], a medicine used to treat epileptic…
A:
Q: 1- Arrange the following compounds in order of decreasing reactivity towards hydrolysis. 2- Arrange…
A: Electron-withdrawing groups include the NO2 and CHO groups. They use the negative resonance effect…
Q: Verapamil, a coronary artery vasodilator, is used in the treatment of angina caused by insufficient…
A: The product of ethyl chloroformate and an amine is ethyl carbamate.
Q: Solenopsin is an alkaloid found in the venom of fire ants. It is considered to be responsible for…
A: Here we are required to find the Starting material required for the formation of solenopsin
Q: What structural and/or molecular properties of aldehyde/ketonecontributes to their reactivity with…
A: Ag2O+4NH3+H2O→2Ag(NH3)+2+ 2OH− (Tollens reagent)
Q: (b) With proper reasoning, provide the retrosynthesis and forward synthesis for the following…
A:
Q: 7. The addition of organometallic compounds to carbonyls is one of the reactions of great interest…
A: Interpretation: To complete the synthesis route and perform reaction mechanism of formation of B.…
Q: D is an intermediate in the synthesis of rosiglitazone (trade name Avandia), a drug used to treat…
A: Body cells secrete many hormones which balance a person's metabolism. Hormones are basically…
Q: Sebatian N Compound N
A: Answer:- This question is answered by using the simple concept of chemical reactions of organic…
Q: Suggest two different synthesis pathways (not more than two reactions each) for the formation of any…
A: Given: An Aldehyde N which is to be converted to ketone. It can be done in following two ways:…
Q: Describe how the following compounds could be prepared from cyclohexanone using an enamine…
A: (a) Cyclohexanone when treated with pyrrolidine in the trace amount of acid, an enamine intermediate…
Q: Verapamil, a coronary artery vasodilator, is used in the treatment of angina caused by insufficient…
A: When C react with 1-bromo-3-chloropropane then there is two possibility that nitrogen lone pair can…
Q: Draw the mechanism of Acid-Catalyzed Keto–Enol Interconversion.
A: Keto refers to the ketone functional group, and enol comes from 'ene' as in alkene, a carbon carbon…
Q: Identify M in the following reaction sequence used to prepare the antiulcer drug omeprazole (trade…
A: To find: The structure of M
Q: How to Identify the Acetylide Anion and Epoxide Needed to Synthesize an Alcohol ?
A: Epoxides are the cyclic ethers which are three membered and one of the vertices is occupied by…
Q: The Stork reaction is a condensation reaction between an enamine donor and an α,β-unsaturated…
A: The structure of enamine formed is drawn as,
Q: 5. Outline a synthesis process to synthesize propyl acetate.
A: Synthesis of Propyl Acetate : It is synthesized by the esterification reaction of acetic acid and…
Q: 4. Provide a reasonable retrosynthetic route that involves a diazonium salt intermediate to…
A: First we can write the synthesis steps from starting material to get target molecule. The given…
Q: CEN ОН
A:
Q: 2. Ethinylestradiol is the ovulation inhibitor component contained in many birth control pills and…
A:
Q: A step in a synthesis of PGE1 (prostanglandin E1, alprostadil) is reaction of a trisubstituted…
A: Bromination of alkene produce an bromonium ion intermediate. This bromonium formed stereoselective…
Q: According to the pharmacopoeia, the diphenylamine reaction is an authenticity reaction to? A)…
A: Sodium nitrite (NaNO2) is an oxidising agents oxidise diphenylamine giving deep blue colour.
Q: I
A: The nucleophilic addition reaction are those reaction in which a nucleophile attacks on an…
Q: CEN он
A: We have given that Propose a multistep synthesis to prepare the following compound ?
Q: What is the intermédiate state of an acid-base catalysis during conversion of DHAP to GAP called,…
A:
Q: Tranexamic acid, a drug useful against blood clotting, is prepared commercially from…
A: NBS (N-bromosuccinimide) is the most commonly used reagent to produce low concentrations of bromine.…
Trending now
This is a popular solution!
Step by step
Solved in 3 steps with 3 images
- Etoposide, sold as a phosphate derivative with the trade name of Etopophos, is used for the treatment of lung cancer, testicular cancer, and lymphomas. (a) Locate the acetals in etoposide. (b) What products are formed when all of the acetals are hydrolyzed with aqueous acid?Identify A, B, and C, three intermediates in the synthesis of the pain reliever and anesthetic fentanyl.Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular reaction to yield rofecoxib. Rofecoxib is a nonsteroidal antiinflammatory agent once marketed under the trade name Vioxx, now withdrawn from the market because of increased risk of heart attacks from long-term use in some patients. Identify Y and draw a stepwise mechanism for its conversion to rofecoxib
- Draw a stepwise mechanism for the conversion of lactone C to carboxylic acid D. C is a key intermediate in the synthesis of prostaglandins (Section 19.6) by Nobel Laureate E. J. Corey and co-workers at Harvard University.Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular reaction to yield rofecoxib. Rofecoxib is a nonsteroidal anti-inammatory agent once marketed under the trade name Vioxx, now withdrawn from the market because of increased risk of heart attacks from long-term use in some patients. Identify Y and draw a stepwise mechanism for its conversion to rofecoxib.Identify M in the following reaction sequence used to prepare theantiulcer drug omeprazole (trade name Prilosec).
- Identify compounds A and B, two synthetic intermediates in the 1979 synthesis of the plant growth hormone gibberellic acid by Corey and Smith. Gibberellic acid induces cell division and elongation, thus making plants tall and leaves large.Aprepitant (trade name Emend) is used to prevent the acute nausea and vomiting caused by chemotherapy. Identify E and F, intermediates in the synthesis of aprepitant.Aspartame, the sweetener used in the commercial products NutraSweet and Equal, is 200 times sweeter than sucrose. What products will be obtained ifaspartame is hydrolyzed completely in an aqueous solution of HCl?
- Etoposide, sold as a phosphate derivative with the trade name ofEtopophos, is used for the treatment of lung cancer, testicular cancer,and lymphomas. What products are formed when all of the acetals are hydrolyzed with aqueous acid?Jiadifenin is a natural product isolated from the fruit of the Chinese plant Illicium jiadifengpi, which has potential for use in treating neurodegenerative disease. The lactone in jiadifenin is formed in the following two-step reaction. Write a stepwise mechanism for the conversion of M to N.18.65 Propose a plausible synthesis for the following trans- formation. CH3 CH3 CH3