Answered: The following diagram is from a paper…

The following diagram is from a paper investigating the role of B4 integrin in breast cancer. They exarmined t Increasing relative C expression B4- B4+ MIRNA

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter16: Gene Expression

Section: Chapter Questions

Problem 33CTQ: Describe how RBPs can prevent miRNAs from degrading an RNA molecule.

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Concept explainers

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.

Question

The following diagram is from a paper investigating the role of β4 integrin in breast cancer. They examined the expression of miRNAs (rows) in ten β4 positive and ten β4 negative breast cancers. Each array was performed in triplicate (columns) (Gerson, 2012).

B. β4 integrin is normally involved in attaching epithelial cells to the extracellular matrix and holding them in place, but in cancer, it can be involved in attaching cells to actin and increasing motility as well as in cell signaling. How is β-integrin expression related to miRNA expression? What do you think this means for these breast cancers?

The following diagram is from a paper investigating the role of B4 integrin in breast cancer. They exarmined t
Increasing
relative
C
expression
B4-
B4+
MIRNA

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