The degradation of the antibiotic clindamycin stored at 343 K in aqueous solution at pH 4 is found to be first order with a rate constant of 2.49 x 10−7 s −1. Over the temperature range 320 K to 360 K the activation energy was found to be 123.3 kJ mol−1. (a) Calculate the rate constant at 325 K. (b) The threshold for product safety is 1% degradation. At 295 K the time taken for 1% of the antibiotic to degrade is found to be close to 0.01/ k. Comment on the shelf-life of the drug.
The degradation of the antibiotic clindamycin stored at 343 K in aqueous solution at pH 4 is found to be first order with a rate constant of 2.49 x 10−7 s −1. Over the temperature range 320 K to 360 K the activation energy was found to be 123.3 kJ mol−1. (a) Calculate the rate constant at 325 K. (b) The threshold for product safety is 1% degradation. At 295 K the time taken for 1% of the antibiotic to degrade is found to be close to 0.01/ k. Comment on the shelf-life of the drug.
Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter11: Chemical Kinetics: Rates Of Reactions
Section: Chapter Questions
Problem 113QRT
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The degradation of the antibiotic clindamycin stored at 343 K in aqueous solution at pH 4 is found to be first order with a rate constant of 2.49 x 10−7 s −1. Over the temperature range 320 K to 360 K the
activation energy was found to be 123.3 kJ mol−1.
(a) Calculate the rate constant at 325 K.
(b) The threshold for product safety is 1% degradation. At 295 K the time taken for 1% of the antibiotic to degrade is found to be close to 0.01/ k. Comment on the shelf-life of the drug.
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