Sulfanilamide, a sulfur drug, acts as an antibiotic. Explain its mechanism of action in the context of enzyme inhibition.
Sulfanilamide, a sulfur drug, acts as an antibiotic. Explain its mechanism of action in the context of enzyme inhibition.
Medical Terminology for Health Professions, Spiral bound Version (MindTap Course List)
8th Edition
ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Chapter2: The Human Body In Health And Disease
Section: Chapter Questions
Problem 43WPR
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Question
1. Sulfanilamide, a sulfur drug, acts as an antibiotic. Explain its mechanism of action in the context of enzyme inhibition.
2. Methotrexate is used in cancer chemotherapy. Explain how this compound works by elaborating on the type of enzyme inhibition involved for its action.
3. For the following aspartate reaction in the presence of inhibitor, Km = 0.00065 M. Determine Vmax in both reactions and in the reaction without inhibitor, the Km. Identify whether the inhibition is competitive, non-competitive or uncompetitive. ( see attached picture )
- 3a. how I and S bind to the E as shown by the Lineweaver Burk plot.
- 3b. the significance of the following obtained values for Km and Vmax.
- 3c. effect in slope and x-intercept
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