Need help, please. Not too sure why my answer is correct. Please explain. Shown below is the titration curve for an amino acid.OH1412108642OU00Aс05B1.01.5ED2.0[OH ] (equivalents)G2.5FWhich point represents the pKa of the R group? D3.0How many ionizable groups does this amino acid have? threev threeVDV✓What is the first point on this curve that 100% of the a-carboxyl group is completely deprotonated? CVcVAt ph=12, what is the protonation state and charge of the alpha-amino group of this amino acid? deprotonated no charge✓deprotonated no charge

Titration curve Titration is how we determine the amount of acid in a solution. A measured amount of…

Shown below is the titration curve for an amino acid. pH 14 12 10 H 8 4) 2 95 00 A C 05 B 1.0 1.5 E D 2.0 [OH ] (equivalents) G 2.5 F Which point represents the pKa of the R group? D 30 3.0 How many ionizable groups does this amino acid have? three DOV three ✓ What is the first point on this curve that 100% of the a-carboxyl group is completely deprotonated? C At ph=12, what is the protonation state and charge of the alpha-amino group of this amino acid? deprotonated no charge deprotonated no charge ✓

Shown below is the titration curve for an amino acid. pH 14 12 10 H 8 4) 2 95 00 A C 05 B 1.0 1.5 E D 2.0 [OH ] (equivalents) G 2.5 F Which point represents the pKa of the R group? D 30 3.0 How many ionizable groups does this amino acid have? three DOV three ✓ What is the first point on this curve that 100% of the a-carboxyl group is completely deprotonated? C At ph=12, what is the protonation state and charge of the alpha-amino group of this amino acid? deprotonated no charge deprotonated no charge ✓

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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In the figures are the titration curves of two amino acids. Consider the first titration. 00 000 pH 10.0 4 14.0 10 9 12.0 3 نیا 8.0 Select the pK, values of each functional group observed on the titration curve. 2 9 6.0 40 20 0.0 0.5 1.0 1.5 2.0 2.5 3.0 equivalents of [CH] Identify which amino acid is being titrated. arginine asparagine histidine lysine
Stereochemistry in biological molecules is often denoted by the D- and L- convention, instead of the R- and S- configurations determined by the Cahn-Ingold-Prelog methodology. Naturally occurring α-amino acids are typically in the L-configuration. The Fischer projection of L-alanine is shown. L-alanine H₂N- H3C- HOOC Identify which structures are equivalent to the L-configuration. H COOH H CH3 NH₂ -COOH NH₂ CH3 -H CH3 COOH H -NH₂ H₂N- H CH3 COOH NH₂ H CH3 -COOH
Based on the following titration table of Glycine, would you be able to recreate the same for Histidine? Glicina Increasing pH H-N-CH,-COOH -H-N-CH,-co = H-N-CH,-C00- Net charge: +1 pH COOH-pKa = 2.3 NH3-pka = 9.6 CN AEq +1 +1 2.3 (0.5°-1)+(0.5°0)=-0.5 +0.5 0.5 9.6 -1 (0.5*+1)+(0.5°0)=+0.5 -0.5 1.5 14 Given that the pKas for Histidine are the following: pka1 = 1.82 pKa2 = 9.17 pКаз %3 6.00 pL = 7.59 2.
The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the relevant acid dissociation constants (pKa). NH,* PK, - 10.79 - HạN*CH2CO,¯ S pK¸=2.35 (CH2)4 - H3N*CHCO,- pK,=9,78 lysine (Lys) glycine (Gly) pK, = 9.18 pK, - 2.16 For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of neutral glycine zwitterions to the concentration of protonated cation is 102. On your under each of the following conditions. In the blank, provide the total charge of the dipeptide. (Example: If the charge is two plus write the answer simply as 2, if the charge is negative two write the answer as -2). draw the skeletal structure of the dipeptide, Lys-Gly, when it is solvated in an aque us solution i. pH= 1 ii. pH= 12
Consider the second titration. 0 0 0 0 0 0 0 ☐☐☐ PH 100/ | 3 14.0 4 12.0 2 8.0 6.0 Select the pK, values of each functional group observed on the titration curve. 4.0 2.0 0.0 0.5 1.0 1.5 2.0 2.5 3.0 equivalents of [OH"] Identify which amino acid is being titrated. alanine aspartate histidine asparagine
Stereochemistry in biological molecules is often denoted by the D- and L- convention, instead of the R- and S- configurations determined by the Cahn-Ingold-Prelog methodology. Naturally occurring a-amino acids are typically in the L-configuration. The Fischer projection of L-alanine is shown. L-alanine H₂N- COOH H- CH3 Identify which structures are equivalent to the L-configuration. CH3 H -NH₂ COOH H COOH NH₂ -CH3
Match each charge form of alanine under the pH condition where it would be the predominant form. The pka values for the carboxyl group and amino group of alanine are approximately 2.3 and 9.7, respectively. H H H Н.С — с — соо H Н.С — с — соо Н.С— с —соон Нс — с —соон NH, NH, NH NH, A B D v pH11 2. A Does not occur in significant amounts at any pH 3. D 4. B
Determine the net charge (to the nearest integer) on the following peptide at pH 5 AND pH 12. Estimate the isoelectric point (pl) for this peptide: H2N-Leu-Gly-Lys-Glu-COOH Assume the pK,s for functional groups are: alpha-amino 6. alpha-carboxy sidechain-amino (Lys) 10.5 sidechain-carboxy (Glu) 4.2 O Net charge at pH 5 and 12 is 0 and -2, respectively, pl =6.6 O Net charge at pH 5 and 12 is 0 and -2, respectively, pl =3.1 O Net charge at plH 5 and 12 is +2 and -1, respectively, pl =7.5 O Nct charge at pH 5 and 12 is +1 and -1. respectively,. pl -4.5 2.
Describe the important biochemical properties of carbohydrates and why carbohydrates would be considered polar molecules. A▾ B I X @ F 7
Consider the following dipeptides: AC HE TG LR VK How many of the dipeptides in this group that would stick to an anion exchange column at pH-8? Please give me the whole number as the answer, 0, 1, 2 etc Amino Acid pKac pKaN pKaR 9.8 9.9 97 2.4 Glycine Alanine 23 Valios 222
1. (a) Draw a three-dimensional line structure of (4S,5Z)-4-amino-5,6-difluorohept-5-enal. Place the aldehyde group on the right-hand side of your drawing. (b) Give the Cahn-Ingold-Prelog priority order of the four groups (-C3H3F2. -NH2, -H, -C3H50) at the C4 stereocentre (Highest 1> 2> 3>4 Lowest). 2. Study the curved arrows in the reactions below and provide structures of all the products that form for the given mechanistic step in the following reactions. (a) +0-H (b) H.
Draw the two possible Haworth structures (both alpha and beta anomers) for the following monosaccharides and give their corresponding systematic names. [Show the stepwise process] D-Ribose D-Galactose D- Fructose