Receptors, such as G-protein coupled receptors (GPCRs) are common drug targets. Ligands that target receptors are often characterised as being agonists or antagonists. Explain, with the aid of figures as appropriate, what these two terms mean.
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Receptors, such as G-protein coupled receptors (GPCRs) are common drug targets.
Ligands that target receptors are often characterised as being agonists or
antagonists. Explain, with the aid of figures as appropriate, what these two terms
mean.
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- What is the mode of action of hydrocholathiazide? A) Where, physiologically speaking, does it work. Be as complete as possible including cells, receptors, etc involved.A series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is LIKELY to cause the MOST binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question. phenadoxone derivatives A. Azetidine B. Thiophene C. Oxetane D. Furan E. Pyrrole ترف لي تي في R= -NHThe receptor or drug target in this case was the rat GABAA receptor obtained from homogenised rat brain cortical tissue. Using the same radioligand binding technique, what other way could you look at ligand affinity to GABAA receptors without using GABAA receptors derived from homogenised tissue and What are the advantages/disadvantages to each strategy?
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