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Propose a mechanism for the reaction of pent-1-yne with HBr in the presence of peroxides. Show why anti-Markovnikov orientation results.
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- Rank the following compounds from greatest tendency to least tendency to undergo nucleophilic aromatic substitution: chlorobenzene 1-chloro-2,4-dinitrobenzene p-chloronitrobenzene a. Rank the same compounds from greatest tendency to least tendency to undergo electrophilic aromatic substitution.2) a) Complete the following scheme with needed reagents and Product A and Product B: OH Хон NaH Product A MS has an M* (100%) and M+2 (97%) or 1:1 Product B Product CWhat reagent should be used to carry out the following reaction?
- What product is formed when (R)-2-chloropentane reacts with hydroxide ion in an SN2 reaction?Offer an explanation for the observation that 4-chloropyridine is more reactive toward nucleophiles than 3-chloropyridine.Explain the relevance pi* (antibonding) -molecular orbitals have in nucleophilic addition reactions of carbonyl containing compounds.
- Explain why 92% of 2,4-pentanedione exists as the enol tautomer in hexane but only 15% of this compound exists as the enol tautomer in water. The enol tautomer can form hydrogen bonds both with hexane and water, but the keto tautomer can form hydrogen bonds with water only. Neither the keto nor the enol tautomer can form hydrogen bonds with hexane, but the keto tautomer can form a hydrogen bond with water, which stabilizes it. The keto tautomer can form hydrogen bonds both with hexane and water, but the enol tautomer can form hydrogen bonds with water only. Neither the keto nor the enol tautomer can form hydrogen bonds with hexane, but the enol tautomer can form an intramolecular hydrogen bond, which stabilizes it.Provide the appropriate reagent(s) for the following transformationProvide the reagents necessary to complete the following transformation. CH, -CH3 OH
- Identify the lettered compounds in each reaction sequence.Draw the product formed when phenylacetonitrile (C6H5CH2CN) istreated with below reagent. H2O, −OHRank the attached compounds in order of increasing reactivity in asubstitution reaction with −CN as nucleophile.Which reagent(s), if any, may be used to carry out the following reaction?