PART I. Explain the relationship of sensitivity and specificity as shown in the diagram. 1. 2. Sensitivity Specificity Specificity ↑ Sensitivity >↑ False positive False negative
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- Please ASAP. Thanku. Sensitization is the same as activation. True FalseWhat is combined therapy? In the light of combinational therapy, Eplain PTT and PDT by suggesting the choice of 2 different sensitizers that would justify the therapeutic approach.16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose (Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one copy of the active Type A Transferase, those with Type B have at minimum one copy of the active Type B Transferase, those with Type AB have one active copy of each, those with Type O have neither. Imagine an AB individual who acquires a mutation in their Type B Transferase gene that allows it to be active with either Gal or GalNAc. Make sure to include a brief justification for your answer to each question below. a. What blood type antigens would this individual express? b. If this individual had a child with a normal O partner, what possible blood type antigens could the child express? c. If this individual had a child with a homozygous dominant B partner (BB), what possible blood type antigens could the child express?
- 1. Match the type of hypersensitivity reaction with their cause. Type IV hypersensitivity reaction Type II hypersensitivity reaction Type III hypersensitivity reaction A. Effector T cells specific for the sensitizing Ag B. Immune complexes formed from IgG binding to soluble Ag C. Antibodies specific for altered components of human cells 2. Because the FceRI receptors on mast cells, basophils and eosinophils always have IgE bound, they have Ag-specific receptors that function similar to B and T cells. Of the following list of characteristics, which ones are unique to Mast cells, basophils, and eosinophils? Choose all that apply. A. Binding antigen triggers differentiation B. Many different IgEs can be found on the surface of one cell C. All of the IgEs on the surface of a…TABLE 6 | Correlation between immune markers and age. Marker NCI PAN LCI LP NK activity (lysis %) R Spearman -0.406 -0.305 -0.239 -0.204 -0.016 Р 0.004 0.035 0.101 0.165 0.913 NCI, Neutrophil Chemotaxis Index; PAN, phagocytic activity of neutrophils; LCI, Lymphocyte Chemotaxis Index; LP, lymphocyte proliferation; NK, natural killer. p is the associated value to the corresponding statistical test.<What is the biomarker of Treg cell and is related to IL-2 receptors?> 1. CD4 2.CD19 3.CD25 4.FoxP3 5.GATA3 The answer is either 3 or 4. I think FoxP3 is more definitive marker of Treg, But CD25 is more relevant to IL-2receptor Can you choose 1 answer?
- 2. https://doi.org/10.1186/s12868-022-00692-1 (link to research) a) In the immunohistochemistry section of the materials and methods section the authors wrote “The number of positive cells in hotspot areas in ten high power fields (HPFs) in areas of demyelination and plaques in the brain stem were counted using the image analysis software (Lecia Application Suite Version 4.12.0, Welzlar, Germany).” Why were they looking at demyelination areas for this study? b) In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Active plaques revealed inflammatory cellular infiltrates with abundant macrophages stuffed with myelin debris, an evidence of ongoing myelin breakdown.” What does macrophages stuffed with myelin debris have to do with the study?The autoimmune attack on nAChR leads to a decrease in the number of available receptors due to antibodies binding to the receptors. 2. Where could you find these antibodies binding? Choose ALL that apply. a. effectors of the parasympathetic nervous system b. effectors of the somatic nervous system c. effectors of the sympathetic nervous system d. pre-ganglionic neurons of the parasympathetic nervous system e. pre-ganglionic neurons of the sympathetic nervous system f. post-ganglionic neurons of the parasympathetic nervous system g. post-ganglionic neurons of the sympathetic nervous system PLEASE EXPLAIN YOUR REASONING!<What is the biomarker of Treg cell and is related to IL-2 receptors?> 1. CD4 2.CD19 3.CD25 4.FoxP3 5.GATA3
- please help All of the following apply to allergic responses (Type I Hypersensitivities) EXCEPT: (choose what does not apply) / Resources and O A. a lack of signs and symptoms during sensitization • B. IgE secretion in the presence of the allergen O C. IgE binding to the IgE receptor on mast cells O D. binding of allergen to MHC I molecules O E. allergic signs and symptoms occur during the secondary response to the allergen O F. all of the above apply, no exception.1. What is an antiserum? 2. What are the potency requirements in an antiserum? ANSWERS TO QUESTIONS ON LABORATORY ASSAY NO.4 3. What kind of antigen will anti-A detect? Anti-B? 4. Enumerate the common causes of false positive and false negative result in ABO forward grouping? 5. Give the purpose of Blood typing. 6. Cite the biochemical components of the ABO blood group accordingly. 7. Complete the table below Blood type A B 0 AB (positive/pos) for agglutination (negative/neg) for no agglutination Anti-A Anti-BPRACTICE EVALUATING CLAIMS Social media posts reveal that not everyone agrees on or accepts the important role of herd immunity, as strongly stated in the blog post below. The fact is that CDC works for big pharma/special interests not public safety as the CDC whistle blower documents prove. The fact is that this is about money not public safety. The fact is that some of these vaccines have little benefit/effectiveness and serious risks. The fact is real natural immunity and vaccine derived immunity are not the same thing at all and our babies would be protected from many/most infectious diseases if their mothers were allowed to have natural immunity and pass it to their babies in breast milk, and we had true herd immunity through adults who had lifelong natural immunity. The fact is vaccine induced immunity typically does not hold for long and often misses the target, and the neurotoxins and foreign ingredients/DNA, etc. are causing a generation of allergic/arthritic/immune system…