| BRCA1 is a bi-allelic gene (let's call the two alleles as C and c) that is inherited on an autosome. The C allele is completely dominant over c, expressing breast cancer as a phenotype. Eye color is determined by two independently assorting bi-allelic genes, B (alleles B and b) and G (alleles G and g), such that the B allele shows dominant epistasis over the G and g alleles. Brown-eyed individuals have at least one copy of the B allele, green eyed individuals have at least one G allele, while blue eyed individuals have neither B nor G. A blue-eyed person whą is a heterozygote carrier for the BRCA1 gene has 3 children with a brown-eyed person (heterozygote for both B and G genes) who does not have breast cancer. (a) What are the possible genotypes and phenotypes of all their possible children? What are their respective probabilities of being observed (please write all genotype and phenotype probabilities)? (h) What is the probability that all three children will be blue-eyed and not have breast cancer?

| BRCA1 is a bi-allelic gene (let's call the two alleles as C and c) that is inherited on an autosome. The C allele is completely dominant over c, expressing breast cancer as a phenotype. Eye color is determined by two independently assorting bi-allelic genes, B (alleles B and b) and G (alleles G and g), such that the B allele shows dominant epistasis over the G and g alleles. Brown-eyed individuals have at least one copy of the B allele, green eyed individuals have at least one G allele, while blue eyed individuals have neither B nor G. A blue-eyed person whą is a heterozygote carrier for the BRCA1 gene has 3 children with a brown-eyed person (heterozygote for both B and G genes) who does not have breast cancer. (a) What are the possible genotypes and phenotypes of all their possible children? What are their respective probabilities of being observed (please write all genotype and phenotype probabilities)? (h) What is the probability that all three children will be blue-eyed and not have breast cancer?

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter19: Introduction To Genetics

Section: Chapter Questions

Problem 9CT

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