OMgBr R'-C-R" + R-MgBr H20 → R'-Ć-R" OH R'-C—R"+ Mg(ОН)Br Ř

Introductory Chemistry: An Active Learning Approach
6th Edition
ISBN:9781305079250
Author:Mark S. Cracolice, Ed Peters
Publisher:Mark S. Cracolice, Ed Peters
Chapter22: Biochemistry
Section: Chapter Questions
Problem 63E
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Some of the most useful compounds for organic synthesisare Grignard reagents (general formula R-MgX, where X is ahalogen), which are made by combining an alkyl halide, R-X,with Mg. They are used to change the carbon skeleton of a start-ing carbonyl compound in a reaction similar to that with R-Li:.(a) What is the product, after a final step with water, of thereaction between ethanal and the Grignard reagent of bromo-benzene? (b) What is the product, after a final step with water, ofthe reaction between 2-butanone and the Grignard reagent of2-bromopropane? (c) There are often two (or more) combina-tions of Grignard reagent and carbonyl compound that will givethe same product. Choose another pair of reactants to give theproduct in (a). (d) What carbonyl compound must react with aGrignard reagent to yield a product with the -OH group at theendof the carbon chain? (e) What Grignard reagent and carbonylcompound would you use to prepare 2-methyl-2-butanol?

OMgBr
R'-C-R" + R-MgBr
H20
→ R'-Ć-R"
OH
R'-C—R"+ Mg(ОН)Br
Ř
Transcribed Image Text:OMgBr R'-C-R" + R-MgBr H20 → R'-Ć-R" OH R'-C—R"+ Mg(ОН)Br Ř
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