nsulin is a protein that allows sugar (glucose) to enter the body's cells (mainly liver, adipose tissue and skeletal muscle). This hormone plays a key role in the regulation of glucose levels in the blood ('hypoglycemic' effect). It is produced by the beta cells in the pancreas. A piece of the gene sequence that encodes for insulin contains: 5’ ATG-GCC-CTG-TGG-ATG-CGC-CTC-CTG-CCC-CTG-CTG-GCG-CTG-CTG-GCC-CTC-TGG-GGA-CCT-GAC- CCA-GCC-GCA-GCC-TTT-GTG-AAC-CAA-CAC-CTG-TGC-GGC-TCA-CAC-CTG-GTG-GAA-GCT-CTC-TAC-CTA-GTG-TGC-GGG-GAA-CGA-GGC-TTC-TTC-TAC-ACA-CCC-AAG-ACC-CGC-CGG-GAG-GCA-GAG-GAC-CTG-CAG-GTG-GGG-CAG-GTG-GAG-CTG-GGC-GGG-GGC-CCT-GGT-GCA-GGC-AGC-CTG-CAG-CCC-TTG-GCC-CTG-GAG-GGG-TCC-CTG-CAG-AAG-CGT-GGC-ATT-GTG-GAA-CAA-TGC-TGT-ACC-AGC-ATC-TGC-TCC-CTC-TAC-CAG-CTG-GAG-AAC-TAC-TGC-AAC-TAG 3’ d. Mutation of codon 34 (CAC to GAC) and 85 (CGT to CAT) of the insulin gene causes hyperinsulinemia which may contribute to diabetes. Identify the amino acid replacement from these mutations. e. Approximately 18% of the double-stranded DNA of the insulin gene is adenine, what are the percentages of the other bases? f. The insulin gene (double-stranded DNA with 666 nucleotide). Given that 120 nucleotides of the DNA has the adenine bases, how many nucleotides contain thymine, guanine and cytosine? Given that information, can you determine the bases composition of the m-RNA? If so, what is it? a. Mutation of codon 34 (CAC to GAC) and 85 (CGT to CAT) of the insulin gene causes hyperinsulinemia which may contribute to diabetes. Identify the amino acid replacement from these mutations. b. Approximately 18% of the double-stranded DNA of the insulin gene is adenine, what are the percentages of the other bases? c. The insulin gene (double-stranded DNA with 666 nucleotide). Given that 120 nucleotides of the DNA has the adenine bases, how many nucleotides contain thymine, guanine and cytosine? Given that information, can you determine the bases composition of the m-RNA? If so, what is it?
1. Insulin is a protein that allows sugar (glucose) to enter the body's cells (mainly liver, adipose tissue and skeletal muscle). This hormone plays a key role in the regulation of glucose levels in the blood ('hypoglycemic' effect). It is produced by the beta cells in the pancreas.
A piece of the gene sequence that encodes for insulin contains:
5’ ATG-GCC-CTG-TGG-ATG-CGC-CTC-CTG-CCC-CTG-CTG-GCG-CTG-CTG-GCC-CTC-TGG-GGA-CCT-GAC- CCA-GCC-GCA-GCC-TTT-GTG-AAC-CAA-CAC-CTG-TGC-GGC-TCA-CAC-CTG-GTG-GAA-GCT-CTC-TAC-CTA-GTG-TGC-GGG-GAA-CGA-GGC-TTC-TTC-TAC-ACA-CCC-AAG-ACC-CGC-CGG-GAG-GCA-GAG-GAC-CTG-CAG-GTG-GGG-CAG-GTG-GAG-CTG-GGC-GGG-GGC-CCT-GGT-GCA-GGC-AGC-CTG-CAG-CCC-TTG-GCC-CTG-GAG-GGG-TCC-CTG-CAG-AAG-CGT-GGC-ATT-GTG-GAA-CAA-TGC-TGT-ACC-AGC-ATC-TGC-TCC-CTC-TAC-CAG-CTG-GAG-AAC-TAC-TGC-AAC-TAG 3’
d. Mutation of codon 34 (CAC to GAC) and 85 (CGT to CAT) of the insulin gene causes hyperinsulinemia which may contribute to diabetes. Identify the amino acid replacement from these mutations.
e. Approximately 18% of the double-stranded DNA of the insulin gene is adenine, what are the percentages of the other bases?
f. The insulin gene (double-stranded DNA with 666
a. Mutation of codon 34 (CAC to GAC) and 85 (CGT to CAT) of the insulin gene causes hyperinsulinemia which may contribute to diabetes. Identify the amino acid replacement from these mutations.
b. Approximately 18% of the double-stranded DNA of the insulin gene is adenine, what are the percentages of the other bases?
c. The insulin gene (double-stranded DNA with 666 nucleotide). Given that 120 nucleotides of the DNA has the adenine bases, how many nucleotides contain thymine, guanine and cytosine? Given that information, can you determine the bases composition of the m-RNA? If so, what is it?
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