Many people of Asian ancestry have alcohol dehydrogenase enzymes that are far more efficient than people of European descent. (This question is based on published results, examples were chosen based on greatest differences, but the numbers given are fictional.) 0.5 0.48 0.46 KA -Z --European 0.44 0.42 0.4 0.38 0.36 0.34 0.32 0.3 0 1 X Y Z 2 3 Time (hours) VW 4 35 5 30 10 5 0 0 1 2 Time (hours) 4 5 -W -V Description: Graph 1. Blood alcohol concentration on vertical axis, time on horizontal. Four lines all start at 0.4. European line decreases over time to 0.34. X increases from 0.4 to 0.46. Y stays at 0.4 over time. Z decreases fastest. Graph 2. Acetaldehyde (in micromolar) on vertical axis, time on horizontal. Three lines all start at 10 micromolar. European line increases to 25 micromolar, then decreases to 23. V line increases from 10 to 30, then to 32, then decreases to 30. W line decreases from 10 to 8 then down to 2. --European Assuming that the acetaldehyde dehydrogenase acts at the same rate, which lines correspond to someone with a very efficient aclohol dehydrogenase (Asian ancestry)? and

Many people of Asian ancestry have alcohol dehydrogenase enzymes that are far more efficient than people of European descent. (This question is based on published results, examples were chosen based on greatest differences, but the numbers given are fictional.) 0.5 0.48 0.46 KA -Z --European 0.44 0.42 0.4 0.38 0.36 0.34 0.32 0.3 0 1 X Y Z 2 3 Time (hours) VW 4 35 5 30 10 5 0 0 1 2 Time (hours) 4 5 -W -V Description: Graph 1. Blood alcohol concentration on vertical axis, time on horizontal. Four lines all start at 0.4. European line decreases over time to 0.34. X increases from 0.4 to 0.46. Y stays at 0.4 over time. Z decreases fastest. Graph 2. Acetaldehyde (in micromolar) on vertical axis, time on horizontal. Three lines all start at 10 micromolar. European line increases to 25 micromolar, then decreases to 23. V line increases from 10 to 30, then to 32, then decreases to 30. W line decreases from 10 to 8 then down to 2. --European Assuming that the acetaldehyde dehydrogenase acts at the same rate, which lines correspond to someone with a very efficient aclohol dehydrogenase (Asian ancestry)? and

Cardiopulmonary Anatomy & Physiology

7th Edition

ISBN:9781337794909

Author:Des Jardins, Terry.

Publisher:Des Jardins, Terry.

Chapter7: Acid–base Balance And Regulation

Section: Chapter Questions

Problem 10RQ

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Consider the following experimental data from another experiment: [S] 1.5 2.00 2.50 5.00 10.00 V (No inhibitor) mmol ml¹ min¹ 0.167 0.204 0.232 0.313 0.385 V (inhibitor) mmol ml¹¹ min¹¹ 0.115 0.143 0.167 0.250 0.333 Calculate Km and V max and determine whether this inhibitor is competitive, non-competitive or uncompetitive.
The hydrolysis of a substrate, S, by an enzyme has been studied in the lab. The following initial rates, vo, were recorded at different concentrations. [S] (M) Vo (M/min) 2.10-10-4 1.20.10-6 4.20-10-4 3.10.10-6 9.30-10-4 6.30-10-6 1.42-10-3 9.10-10-6 A. Determine the rate constants for degradation of the substrate B. What is the rate of reaction at [S] = 1.1.104 M? C. Explain, why enzymes can make reactions go faster? Does enzymes also catalyse the reverse reaction from product to substrate?
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A scientist is studying the enzyme X which is an important point of regulation in the metabolism of the inhabitants of Sumeru. He developed four Akademiyan-derived compounds which may possibly work against this enzyme, and tested using an eudiometer the metabolic rate of the sample cell lines. Data are below. Time for each compound (min) Eudiometer volume reading (mL) A B C D 0 83.1 62.6 89.0 66.4 5 83.2 100.6 90.2 71.4 10 83.2 83.6 95.0 77.2 15 83.2 83.6 100 84.6 20 83.3 110.8 104.6 88.2 Show the properly labeled volume versus time plot for each eudiometer, with the equation of the line and R2. What is the most effective inhibitor among the four compounds? It was found that the most effective inhibitor exhibits uncompetitive inhibition. Illustrate the Lineweaver-Burk plots of uninhibited and inhibited enzyme X with properly labeled axes.
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