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- What are the normal functions of the BRCA1 tumor suppressor gene?Excessive angiogenesis and reduced apoptosis are two of the six characteristics that define cancerous tumors. Discuss how developing treatments for these two conditions might prevent the development of cancer altogether from pre-malignant tumors.Describe the genetic changes that inactivate tumor-suppressor genes.
- The following are drugs that act as anti-tumor agents and are often used as part ofchemotherapeutic regimens for cancer patients. Explain how the use of the following drugs mayprevent cancer cell growth and/or proliferation.What are the major differences between a tumor initiator (e.g., DMBA) and a tumor promoting agent (e.g., TPA)?Although cancer is not a contagious disease in humans or other vertebrates, there have been rare cases in which cancers have spread from one organism to another. Describe three cases of these contagious cancers and what conditions might have led to their appearance. For an introduction to this topic, see http:// www.cancer.org/cancer/cancerbasics/is-cancer-contagious.
- Is Epithelial-Mesenchymal Transition (EMT) responsible for invasion and/or metastasis of tumors? Explain.Define the following terms: tumor, neoplasia, anaplasia, metastasis, proto-oncogene, oncogene, and tumor suppressor gene.Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancer
- What is a tumour marker? How are tumour markers detected in the body and can they be used diagnostically? Provide one example of a tumour markerExplain why mutations in tumor suppressor genes are recessive (both copies of the gene must be defective for the regulation of cell division to be defective), whereas mutations in oncogenes are dominant.Tissues and differentiation: a) Explain what is meant by determination and differentiation b) Explain the difference between an oncogene and a tumor suppressor gene and describe how they are involved in the development of cancer