Examine the following peptide and the inserted table, and answer the 2 questions below:Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys 1. Estimate the net charge of the peptide at pH 2.0. Explain.2. Estimate the net charge of the peptide at pH 7.0. Explain. GroupAcidBaseTypical pk.Terminal a-carboxyl3.1groupAspartic acidGlutamic acid4.1Histidine6.0+ H-N-NTerminal a-amino group8.0HH.CysteineH'8.3+ H-NLysine-NTH10.8H.Тугosine10.9HHN-HHNArginine12.5N-HHN-HH'O-U

The net charge of peptide molecule depends upon the charge on the amino acids side chain, N-terminal…

Examine the following peptide and the inserted table, and answer the 2 questions below: Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys 1. Estimate the net charge of the peptide at pH 2.0. Explain. 2. Estimate the net charge of the peptide at pH 7.0. Explain.

Examine the following peptide and the inserted table, and answer the 2 questions below: Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys 1. Estimate the net charge of the peptide at pH 2.0. Explain. 2. Estimate the net charge of the peptide at pH 7.0. Explain.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter26: Synthesis And Degradation Of Nucleotides

Section: Chapter Questions

Problem 22P

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Concept explainers

Metabolic pathways

Metabolism is defined as the group of life-supporting, enzyme-mediated chemical reactions in organisms. A metabolic pathway is a set of these chemical reactions that involve anabolism (synthesis of complex biomolecules) and catabolism (breakdown of biomolecules into small molecules) that occur inside a cell. Metabolites are the reacting substances, products, and intermediate substances of an enzymatic process that are altered by a series of chemical events catalyzed by enzymes.

Question

100%

Examine the following peptide and the inserted table, and answer the 2 questions below:

Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys

1. Estimate the net charge of the peptide at pH 2.0. Explain.

2. Estimate the net charge of the peptide at pH 7.0. Explain.

Group
Acid
Base
Typical pk.
Terminal a-carboxyl
3.1
group
Aspartic acid
Glutamic acid
4.1
Histidine
6.0
+ H
-N
-N
Terminal a-amino group
8.0
H
H.
Cysteine
H'
8.3
+ H
-N
Lysine
-N
TH
10.8
H.
Тугosine
10.9
H
H
N-H
H
N
Arginine
12.5
N-H
H
N-H
H'
O-U

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