DNA molecule, which embodies genes, the hereditary units, is found in all living things. Science showed that genes could be expressed in any microorganism, meaning that DNA will direct the synthesis of proteins needed for various biological functions and structures.To reduce the costs of production, pharmaceutical companies use biotechnology to generate human insulin in bacteria.Can you describe the steps leading to the production of this hormone in industrial quantities?

DNA molecule, which embodies genes, the hereditary units, is found in all living things. Science showed that genes could be expressed in any microorganism, meaning that DNA will direct the synthesis of proteins needed for various biological functions and structures.To reduce the costs of production, pharmaceutical companies use biotechnology to generate human insulin in bacteria.Can you describe the steps leading to the production of this hormone in industrial quantities?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 12QP: One unexpected result of the sequencing of the human genome was the finding that mutations in a...

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Suppose that you are hired by a biotechnology firm to produce a strain of giant fruit flies by using recombinant DNA technology so that genetics students will not be forced to strain their eyes when looking at tiny flies. You go to the library and learn that growth in fruit flies is normally inhibited by a hormone called shorty substance P (SSP). You decide that you can produce giant fruit flies if you can somehow turn off the production of SSP. Shorty substance P is synthesized from a compound called XSP in a single-step reaction catalyzed by the enzyme runtase: A researcher has already isolated cDNA for runtase and has sequenced it, but the location of the runtase gene in the Drosophila genome is unknown. In attempting to devise a strategy for turning off the production of SSP using standard recombinant DNA techniques, you discover that deleting, inactivating, or otherwise mutating this DNA sequence in Drosophila turns out to be extremely difficult. Therefore, you must restrict your…
In order to manufacture insulin for patients with diabetes, scientists create recombinant DNA by inserting a human insulin gene into bacterial DNA, and have the bacteria produce human insulin. Using knowledge about gene expression, what must the scientists do to the DNA sequence of the human insulin gene BEFORE inserting into the bacteria, in order to have them produce the same insulin sequence that humans would produce? Explain.
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