e1.00.5-06.Answer the questions below about hemoglobin and myoglobin.a. Sketch and label the binding curves of Mb, Hb, and Hb below.pº₂b. In the scenarios below for Hb, indicate what effect they would have on thebinding curve and give a brief explanation?ScenarioDecrease in theconcentration ofcarbon dioxide(CO₂)Distal histidine(the histidine thataids in molecularoxygen binding)mutation tophenylalanineHigh heat andextreme pHchangesPredict if the normal bindingcurve of Hb will shift right(Hbt), left (HbⓇ), completelyto Mb, or no longer bindoxygen completely?Brief Explanation

The binding curve describes the relationship between the amount of oxygen bound to a molecule of…

Answered: D 1.0. 0.5- O 6. Answer the questions…

Cardiopulmonary Anatomy & Physiology

7th Edition

ISBN:9781337794909

Author:Des Jardins, Terry.

Publisher:Des Jardins, Terry.

Chapter15: Hemodynamic Measurements

Section: Chapter Questions

Problem 1RQ

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Compared to adult Hb (HbA), fetal Hb (HbF) has one less histidine in the central cavity where BPG binds. What is the consequence of this difference in the P50 value? a The P50 value of HbF approaches zero torr at high O2 partial pressures. b The P50 value of HbF approaches 100 torr at high O2 partial pressures. c HbA has a smaller P50 value compared to HbF d HbF and HbA have the same P50 value. e HbF has a smaller P50 value compared to HbA
31 A research student is investigating artificial substitutes for human blood inemergency blood loss situations. For example, a person has suffered a traumaresulting in a large open wound and has lost a large volume of blood. The wound hasbeen temporarily closed and blood loss has been slowed.Consider the above scenario to answer the following questions in sentence format.a. While blood supports many functions, what would be the primary short-termpurpose of artificial blood in this scenario?b. What characteristics would artificial blood need to have in order to functionwell in the body to address acute blood loss?c. What type of tissue is blood?
1. Briefly describe the affect of the glutamic acid to valine mutation on the Hemoglobin protein as it relates to Sickle Cell Anemia. 2. Is your prediction (from question 3 in Part I) consistent with the description of the cause of the sickle-cell anemia disease (from the BME3D computer tutorial)? Explain.
O, saturation curve is shown beloww for hemoglobin at various pHs. Detail this Bohr effect from the molecular perspective. Be sure to include discussion of what causes this (i.e. specific amino acids), why the curves are right shifted with decreasing pH, and why this is logical in delivery of 02 to areas of higher demand. 100 Myoglobin 80- pH 7.6 60 pH 7.4 pll 7.2 40- pH 7.0 pH 6.8 20- Venous 0- 0. 20 10 60 80 Percent saturation
What are the differences in terms of structure and ligand-binding interactions? What are the functions of each type of GPCR?
Q) Following an intensive course of chemotherapy, a 48-year-old woman had a thorough laboratory evaluation, selected results of which are: Hemoglobin 8 g/dL, hematocrit 32% Arterial blood gases: pH 7.38, Pa.CO₂ 42 mm Hg, bicarbonate 25 mEq/L, Pa.O2 62 mm Hg, O₂ saturation 92%. Given that the O2 binding capacity of hemoglobin is 1.34 ml/g, calculate the O2 capacity of her hemoglobin. A) 9.86 ml/dL B) 9.86 mm Hg C) 9.86 mEq/L D) 10.72 ml/dL E) 10.72 mEq/L Ans: D 6.11. Following an intensive course of chemotherapy, a 48-year-old woman had a thorough laboratory evaluation, selected results of which are: Hemoglobin 8 g/dL, hematocrit 32% Arterial blood gases: pH 7.38, Pa.CO₂ 42 mm Hg, bicarbonate 25 mEq/L, Pa.O₂ 64 mm Hg, O₂ saturation 92%. Given that the O2 binding capacity of hemoglobin is 1.34 ml/g, calculate the O2 content of her arterial hemoglobin. A) 9.86 ml/dL B) 9.86 mm Hg C) 9.86 mEq/L D) 10.72 ml/dL E) 10.72 mEq/L Ans: A
{1q}. 1. Why is cyanmethemoglobin method preferred than other methods? 2. In what circumstances is the copper sulfate method used? 3. Discuss the synthesis and breakdown of hemoglobin.?
1) What methods are used to measure glycosylated hemoglobin? 2) What potential conditions might cause erroneous results?
0.3 M Glycerin, 0.3 Urea are both 0.3, but thei effect on RBCs is very different than 0.3 M Glucose. Glycerin = glycerol, which is a non-polar molecule. Urea is a small molecule which passes though membrane easily by facilitated diffusion. Predict the fate of a red blood cell placed in 0.3 M glycerin and in a 0.3 M Urea. Explain why these changes might take place.
Select the hemoglobin variant(s) that are described by each statement. (a) The variant least likely to cause pathological symptoms. (b) The variant(s) likely to show pl values different from that of HbA on an isoelectric focusing gel. (c) The variant most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen. Answer Bank Hb Milwaukee Hb Cowtown Hb Memphis Hb Philly Hb Providence Hb Bibba HbS
A single dose of 300mg of drug is 63% bioavailable by the IM route. The same drug is 42% bioavailable by the oral route. How many 150mg tablets would need to be administered PO BID to achieve plasma levels comparable to the IM dose?
Complete the following table about hemoglobin (Hb) characteristics. Оху-НЬ Deoxy-Hb Conformation [ Select ] [ Select ] ВPG [ Select ] [ Select ] > >

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