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- The peak plasma concentration achieved after the first IV dose of drug X is 25 mg/L. The drug’s half-life is 3.5 hours, and it is administered every 12 hours. What will be the peak plasma concentration at steady state?Calculate the oral loading dose (LD) of digoxin for Miss Jones who weighs 60 kg. The desired plasma concentration (Cp) is 1.5 mcg/L, volume of distribution (Vd) is 7.3 L/kg, the salt factor (S) is 1 and bioavailability fraction (F) is 0.7.Give your answer to the nearest whole number of micrograms.The equation below can be used:Loading Dose = Cp desired x VdS x FSarah who weighs 67 kg is to receive acetylcysteine at a dose of 50 mg/kg infused over 4 hours for paracetamol overdose. The required volume of concentrated acetylcysteine solution (200 mg/mL) has been added to 500 mL of 5% glucose solution. What is the concentration of the solution to be infused (mg/mL)? (Answer to 1 decimal place.) Answer: 16.75 mg x
- The order in the MAR is for Atropine 15 mg IV q6h hours PRN. How many mL will you give if the dosage strength is 75mg/7.5mL?A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mLCalculate the duration of action assuming that the minimum effective concentration is 5mg/L 1000 100 y 400e0916 10 05 15 2. 2.5 Time (hours) Plasma concentration (me/)
- When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/mL) observed over time (hr) can be described by the following equation: C = 3.6e-0.105t C= 3-6e AUC 36 6 -0.105t 5. Calculate AUC(0-0) 0-105 = 34.28 6. What is the volume of distribution? Dose 100 VD= Co 3-6 7. Calculate the clearance of this drug. CI = KXVD CI = 0•105 x 27-8 %3D %3D Cl=2.9 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL?A 79 kg man is admitted to hospital following a suspected overdose of drug G. When he is admitted to hospital on the 3rd October at 23:00 his plasma concentration of drug G is 12 mg/mL. Given that the half-life (t½) of drug G is 10.5 hours. What would you expect his plasma concentration of drug G to be at 17:00 on the 5th October? Give the answer in microg/ml. (You may assume that the distribution is complete and the elimination is described by a 1storder process.)SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 1. Atropine is given in doses of .5mg/kg. How much will a patient who weighs 3.5 lbs receive? An arthritic patient is taking 2 1/2mg of Rymadil three times a day. If each tablet contains 5mg, how many tablets will the patient take in 7 days? 2.
- Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B. The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd S x F Where Cp desired is the target plasma concentration; Vd is the volume of distribution; S is the salt factor and F is the bioavailability fractionThe biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.Ordered: 0.03 g/kg q6h Weight: 60lb (round weight to the nearest tenth) On hand: 200 mg/5mL How many mg per dose is ordered? Per day? The safe range is 3200-3600 mg/day is the ordered dose safe? How many mL will the patient receive per dose? Per day?