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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter10: Reconstitution Of Powdered Drugs

Section: Chapter Questions

Problem 4.5P

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Question

Answer part b

engineer the maltose binding
protein (MBP) to bind 1, 3, 5 Trinitrobenzene (TNB) - a molecule that is even more
explosive than TNT! Instead of its natural ligand, maltose, you hope to develop your
mutant into a biosensor that can be used to detect the presence of land mines through
identification of TNB in the soil.
NO₂
CH₂OH
CH₂OH
OH
OH
å ove
O₂N
NO₂
OH
OH
Maltose
TNB
OH
After the laborious process of mutating the active site of MBP to bind TNB, you identify
four variants of MBP that bind to TNB with the following affinities:
TNB-binding MBP variant
A
B
C
D
KD (μm)
850
9,000
0.4
30
The maximal concentration of TNB that leeches out of land mines into the surrounding
soil reaches only 2 mM (milli-molar). Your advisor asks you to use the Ko values you
measured to determine which of the variants would be the best candidate for the
following purposes. Assume that the fraction of TNB-bound MBP correlates linearly with
a signal in your biosensor device from 0 (completely unbound) to 1 (fully bound).

b. Which variant would be most effective at measuring changes in the concentration
of TNB in regions with and without land mines (i.e., where [TNB] could range
from 0-2 mm). Briefly explain your answer.

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