(b) ☐ The exergonic reactions catalyzed by isocitrate dehydrogenase (ICDH) and α- ketoglutarate dehydroge-nase (aKGDH) are regu- lated by metabolites, in addition to the reaction catalyzed by citrate synthase. The diagram to the right illustrates the activity of ICDH (A,▲) and aKGDH (O,●) in the presence of 1.5 mM ADP (O,A) or 1.5 mM ATP (●,▲). In muscle tissue contraction of sarcomeres initiated by a nerve im- pulse results first in the release of Ca 2+ from the sarcoplasmic reticulum. As indicated by the chang- es in velocity of the two enzymes, what are the flux changes of the TCA cycle in muscle tissue upon release of Ca2+ under the influence of ADP viz. ATP and under the influence of NAD+ viz. NADH on cit- rate synthase? 100 75 Stimulation of activity (% of maximum) ŏ 25 1. -8 -7 -6 log {[Ca2+] (M)}

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter25: Nitrogen Acquisition And Amino Acid Metabolism
Section: Chapter Questions
Problem 12P
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(b) ☐ The exergonic reactions catalyzed by
isocitrate dehydrogenase (ICDH) and α-
ketoglutarate dehydroge-nase (aKGDH) are regu-
lated by metabolites, in addition to the reaction
catalyzed by citrate synthase. The diagram to the
right illustrates the activity of ICDH (A,▲) and
aKGDH (O,●) in the presence of 1.5 mM ADP
(O,A) or 1.5 mM ATP (●,▲). In muscle tissue
contraction of sarcomeres initiated by a nerve im-
pulse results first in the release of Ca 2+ from the
sarcoplasmic reticulum. As indicated by the chang-
es in velocity of the two enzymes, what are the flux
changes of the TCA cycle in muscle tissue upon
release of Ca2+ under the influence of ADP viz. ATP
and under the influence of NAD+ viz. NADH on cit-
rate synthase?
100
75
Stimulation of activity
(% of maximum)
ŏ
25
1.
-8
-7
-6
log {[Ca2+] (M)}
Transcribed Image Text:(b) ☐ The exergonic reactions catalyzed by isocitrate dehydrogenase (ICDH) and α- ketoglutarate dehydroge-nase (aKGDH) are regu- lated by metabolites, in addition to the reaction catalyzed by citrate synthase. The diagram to the right illustrates the activity of ICDH (A,▲) and aKGDH (O,●) in the presence of 1.5 mM ADP (O,A) or 1.5 mM ATP (●,▲). In muscle tissue contraction of sarcomeres initiated by a nerve im- pulse results first in the release of Ca 2+ from the sarcoplasmic reticulum. As indicated by the chang- es in velocity of the two enzymes, what are the flux changes of the TCA cycle in muscle tissue upon release of Ca2+ under the influence of ADP viz. ATP and under the influence of NAD+ viz. NADH on cit- rate synthase? 100 75 Stimulation of activity (% of maximum) ŏ 25 1. -8 -7 -6 log {[Ca2+] (M)}
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