(a) duplicated genes that have lost their function orthologous genes paralogous genes pseudogenes all of these (b) effect of gene duplication that have different function orthologous genes paralogous genes pseudogenes all of these
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(a) duplicated genes that have lost their function
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orthologous genes
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paralogous genes
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pseudogenes
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all of these
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(b) effect of gene duplication that have different function
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orthologous genes
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paralogous genes
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pseudogenes
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all of these
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Solved in 2 steps
- 1. (a) alpha-globin in cow and pig orthologous genes paralogous genes pseudogenes all of these (b) Product of gene mutation orthologous genes paralogous genes pseudogenes all of these1. (a)genes with similar function orthologous genes paralogous genes pseudogenes all of these (b) insulin genes in human and cow orthologous genes paralogous genes pseudogenes all of theseexplain the statement Duplications Provide Extra Gene CopiesThat Can Acquire New Functions
- 6) If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genomeWhen comparing evolutionary similarities between different genes within a gene family, it is usually more straightforward to compare genes by using the protein sequences of gene products rather than DNA sequences of the genes themselves. Explain why this is the case. (Cover 4 points)Which of the following statements regarding gene duplication are FALSE? Select ALL that apply. extra gene copies are highly deleterious duplications arise through unequal crossing over duplicates in the same gene family are called paralogs duplication is an important source of new genes duplications confound the pairing of homologous chromosomes, leading to fertility problems
- 5. Chapter 21 describes two blotting methods (i.e., Northern blottingand Western blotting) used to detect gene products. Northern blottingdetects RNA and Western blotting detects proteins. Supposethat a female fruit fly is heterozygous for a maternal effect gene,which we will call gene B. The female is Bb. The normal allele, B,encodes a functional mRNA that is 550 nucleotides long. A recessiveallele, b, encodes a shorter mRNA that is 375 nucleotideslong. (Allele b is due to a deletion within this gene.) How couldyou use one or more of these techniques to show that nurse cellstransfer gene products from gene B to developing oocytes? Youmay assume that you can dissect the ovaries of fruit flies and isolateoocytes separately from nurse cells. In your answer, describeyour expected results.Which of the following statements is true regarding gene duplication? (Check all that apply) extra gene copies are highly deleterious duplications arise through unequal crossing over duplicates in the same gene family are called paralogs duplication is an important source of new genes duplications confound the pairing of homologous chromosomes, leading to fertility problemsDescribe the medical applications of human gene therapy in the following diseases: Haemophilia, Cystic fibrosis, and Leber congenital amaurosis.
- 1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Please EXCLUDE the use of CRISPR from consideration. A. Will you use germline or somatic cell gene therapy? Please NAME and DEFINE the form of gene therapy selected, then explain WHY this is the most appropriate choice.1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). a) Hypothetically, what specific type of VECTOR will you use to perform your gene therapy? Please select from the following list of potential vectors: disabled retrovirus, adenovirus, adeno-associated virus (AAV), or herpes simplex virus (HSV), then give two reasons why this specific vector is the most appropriate for your gene therapy. Please explain why you were able to rule out the other potential…1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Other scientists have suggested that it might be possible to use CRISPR to treat this genetic disorder in affected individuals. (i) First, what is CRISPR? (BRIEFLY describe what it is and how it works). (ii) Briefly describe how CRISPR could be utilized in treating genetic conditions such as Batten disease.