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Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 5CRQ
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Using a copy of a helical wheel (attached to the end) plot the amino acids of the helix on the helical wheel.  Is there any evidence of the helix as a whole being amphipathic or having a “sidedness"? Explain yes or no.  Are the amino acid side chains in close proximity of one another or staggered to minimize steric hinderance between side chains?  Explain the pattern you observe.

 

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Amino acid Name &
Polar/NonPolar
Charge at pH 7
Number
25-valine
Nonpolar
26- Glycine
Nonpolar
27- Phenylalanine
Nonpolar
28-Alanine
Nonpolar
29-Threonine
polar
30-Arginine
polar
+1
31-Lysine
polar
+1
32-Valine
Nonpolar
33-Alanine
Nonpolar
34-Glycine
Nonpolar
35-Methionine
Nonpolar
36-Alanine
Nonpolar
Transcribed Image Text:Amino acid Name & Polar/NonPolar Charge at pH 7 Number 25-valine Nonpolar 26- Glycine Nonpolar 27- Phenylalanine Nonpolar 28-Alanine Nonpolar 29-Threonine polar 30-Arginine polar +1 31-Lysine polar +1 32-Valine Nonpolar 33-Alanine Nonpolar 34-Glycine Nonpolar 35-Methionine Nonpolar 36-Alanine Nonpolar
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