6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP

37.The equilibrium constant that drives complexation reactions to completion is known as? 36.Eosin Y is also known as

Which of the following substituent is an ortho/para-directing deactivator?   a amino group   b halogen group   c phenyl group   d carboxyl group

1) Listen triacyl glyceraldhyde results in what chemical reaction (based on prior knowledge)? O hydration O dehydration, intermolecular O dehydration, intramolecular dehydrogenation P Type here to search 421 PM hp ort sc delete 144 end g dn home %23 %24 1% 3. 5 6 8 6. um 4 beckspace Vock ab Q R Y U home D IE G H II J K lock A S enter 4 6. ししに pause V B M t shitt 2 3 end alt ctrl in alt

26. Cyclophosphamide is a prodrug converted to nitrogen mustard as shown in the following scheme. Cyclophosphamide is thus classified as HÖ) CI P450 H2N P-N Cyclophosphamide B: H2N H. HPO, + NH3 + HN spontaneous OR phosphoramidase A. Bipartate prodrug B. Tripartite prodrug C. Bioprecursor prodrug D. Mutual prodrug

How did the rate change as the concentration of the S2O8-2 was halved. Expalin at molecular level.

1 Norepinephrine can be metabolized to the following metabolite in two steps as shown below. What might be the enzymes (in the correct order) responsible for these biotransformations? но но но HN -OH но- но но Он OH OH norepinephrine COMT / MAO MAO / Cyp450 MAO / Aldehyde dehydrogenase Сур450 / МАО

Provide an electron pushing mechanism for the conversion shown below. Abbreviate the enzyme catalyst active site groups (BH* and B:) as needed. Which purine base is used? NH₂ Enz H₂O 'N NH

Covalent enzyme catalysis involves the formation of a transient covalent bond between an enzyme and its substrate Below is the general structure of a commonly encountered so-called acyl-enzyme intermediate Ent- NH OH+Ent Select amino acid residues from the table beliow that have side chains with the enzyme reactive groups indicated in the above reaction (if more than one, start with lowest numbered first. Amino acid No 3-detter code What is the chemical name of the acyl-enzyme intermediate compound (acylimidazole, anhydride, ester, Schif base, thioester? 2) 3 HN HO HO HO HO (5) 6 HN HD HO HN HO HO 03 15 HN HN HO HO HO HO 08 09 20 HO

please explain why this happends, im having trouble in this section. Part A Chymotrypsin, an enzyme that hydrolyzes peptide bonds in proteins, functions in the small intestine at an optimum pH of 7.7 to 8.0. How is the rate of the chymotrypsin-catalyzed reaction affected by each of the following conditions?